Blood-brain barrier dysfunction amplifies the development of neuroinflammation: understanding of cellular events in brain microvascular endothelial cells for …
F Takata, S Nakagawa, J Matsumoto… - Frontiers in cellular …, 2021 - frontiersin.org
Neuroinflammation is involved in the onset or progression of various neurodegenerative
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …
Tissue clearing and its applications in neuroscience
State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …
tissues from individual organs and even to some entire mammals. When combined with light …
Transcytosis to cross the blood brain barrier, new advancements and challenges
VM Pulgar - Frontiers in neuroscience, 2019 - frontiersin.org
The blood brain barrier (BBB) presents a formidable challenge to the delivery of drugs into
the brain. Several strategies aim to overcome this obstacle and promote efficient and …
the brain. Several strategies aim to overcome this obstacle and promote efficient and …
Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models
JC Cruz Hernández, O Bracko, CJ Kersbergen… - Nature …, 2019 - nature.com
Cerebral blood flow (CBF) reductions in Alzheimer's disease patients and related mouse
models have been recognized for decades, but the underlying mechanisms and resulting …
models have been recognized for decades, but the underlying mechanisms and resulting …
Mapping the fine-scale organization and plasticity of the brain vasculature
The cerebral vasculature is a dense network of arteries, capillaries, and veins. Quantifying
variations of the vascular organization across individuals, brain regions, or disease models …
variations of the vascular organization across individuals, brain regions, or disease models …
Machine learning analysis of whole mouse brain vasculature
Tissue clearing methods enable the imaging of biological specimens without sectioning.
However, reliable and scalable analysis of large imaging datasets in three dimensions …
However, reliable and scalable analysis of large imaging datasets in three dimensions …
Neuronal regulation of the blood–brain barrier and neurovascular coupling
L Kaplan, BW Chow, C Gu - Nature Reviews Neuroscience, 2020 - nature.com
To continuously process neural activity underlying sensation, movement and cognition, the
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …
The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting
CS Von Bartheld, J Bahney… - Journal of …, 2016 - Wiley Online Library
For half a century, the human brain was believed to contain about 100 billion neurons and
one trillion glial cells, with a glia: neuron ratio of 10: 1. A new counting method, the isotropic …
one trillion glial cells, with a glia: neuron ratio of 10: 1. A new counting method, the isotropic …
Single-breath-hold photoacoustic computed tomography of the breast
We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT)
system to reveal detailed angiographic structures in human breasts. SBH-PACT features a …
system to reveal detailed angiographic structures in human breasts. SBH-PACT features a …
Cell densities in the mouse brain: a systematic review
D Keller, C Erö, H Markram - Frontiers in neuroanatomy, 2018 - frontiersin.org
The mouse brain is the most extensively studied brain of all species. We performed an
exhaustive review of the literature to establish our current state of knowledge on cell …
exhaustive review of the literature to establish our current state of knowledge on cell …