The retinoblastoma tumour suppressor (RB) is a crucial regulator of cell-cycle progression
that is invoked in response to a myriad of anti-mitogenic signals. It has been hypothesized …

Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor
and is also intimately involved in tumorigenesis. FOXM1 stimulates cell proliferation and cell …

Rapidly proliferating tumor and immune cells need metabolic programs that support energy
and biomass production. The amino acid glutamine is consumed by effector T cells and …

Blockade of colony-stimulating factor-1 (CSF-1) limits macrophage infiltration and improves
response of mammary carcinomas to chemotherapy. Herein we identify interleukin (IL)-10 …

Abstract Background Cyclin-dependent kinases (CDKs) regulate cell proliferation and
coordinate the cell cycle checkpoint response to DNA damage. Although inhibitors with …

Immune cells comprise a substantial proportion of the tumor mass in human nonsmall cell
lung cancers (NSCLC), but the precise composition and significance of this infiltration are …

Purpose: Anticancer drug development is inefficient, but genetically engineered murine
models (GEMM) and orthotopic, syngeneic transplants (OST) of cancer may offer …

Background Median survival is 10 months and 2-year survival is 20% in metastatic non-
small-cell lung cancer (NSCLC) treated with platinum-based chemotherapy. A small fraction …

The biologic basis of genetic ancestry-dependent variability in disease incidence and
outcome is just beginning to be explored. We recently reported enrichment of a population of …

Our previous studies have found that activation of Wnt/β-catenin signaling resulted in mouse
prostatic intraepithelial neoplasia (mPIN). In the large probasin promoter directed SV40 …