The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Arterial stiffness results from a degenerative process affecting mainly the extracellular matrix
of elastic arteries under the effect of aging and risk factors. Changes in extracellular matrix …

The arterial pulse wave (PW) is a rich source of information on cardiovascular (CV) health. It
is widely measured by both consumer and clinical devices. However, the physical …

In patients with uncomplicated essential hypertension, cardiac output remains within normal
ranges and intravascular volume is normal or low, assuming the presence of a sufficient …

Pathophysiological studies have extensively investigated the structural factor in
hypertension, including large and small artery remodeling and functional changes. Here, we …

Among age-related diseases, cardiovascular and cerebrovascular diseases are major
causes of death. Vascular dysfunction is a key characteristic of these diseases wherein age …

The goal of this review is to provide further understanding of increased vascular stiffness
with aging, and how it contributes to the adverse effects of major human diseases …

In recent years, great emphasis has been placed on the role of arterial stiffness in the
development of cardiovascular diseases. Indeed, the assessment of arterial stiffness is …

Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular
events, dementia, and death. Decreased compliance of the central vasculature alters arterial …

With advancing age, arterial stiffness and wave reflections increase and elevate systolic and
pulse pressures. An elevated central pulse pressure is generally ascribed to increased wave …