[HTML][HTML] Mitochondrial complex I ROS production and redox signaling in hypoxia

CN Okoye, SA Koren, AP Wojtovich - Redox biology, 2023 - Elsevier
Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

PR Angelova, AY Abramov - FEBS letters, 2018 - Wiley Online Library
Mitochondria are key cell organelles in that they are responsible for energy production and
control many processes from signalling to cell death. The function of the mitochondrial …

[HTML][HTML] Breathing matters

CA Del Negro, GD Funk, JL Feldman - Nature Reviews Neuroscience, 2018 - nature.com
Breathing is a well-described, vital and surprisingly complex behaviour, with behavioural
and physiological outputs that are easy to directly measure. Key neural elements for …

[HTML][HTML] Making sense of astrocytic calcium signals—from acquisition to interpretation

A Semyanov, C Henneberger, A Agarwal - Nature Reviews …, 2020 - nature.com
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …

Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

PR Angelova, N Esteras… - Medicinal Research …, 2021 - Wiley Online Library
The world's population aging progression renders age‐related neurodegenerative diseases
to be one of the biggest unsolved problems of modern society. Despite the progress in …

Nrf2 as a regulator of mitochondrial function: Energy metabolism and beyond

N Esteras, AY Abramov - Free Radical Biology and Medicine, 2022 - Elsevier
Mitochondria are unique and essential organelles that mediate many vital cellular processes
including energy metabolism and cell death. The transcription factor Nrf2 (NF-E2 p45 …

Interaction of mitochondrial calcium and ROS in neurodegeneration

AY Baev, AY Vinokurov, IN Novikova, VV Dremin… - Cells, 2022 - mdpi.com
Neurodegenerative disorders are currently incurable devastating diseases which are
characterized by the slow and progressive loss of neurons in specific brain regions …

Carotid body chemoreceptors: physiology, pathology, and implications for health and disease

R Iturriaga, J Alcayaga, MW Chapleau… - Physiological …, 2021 - journals.physiology.org
The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

[HTML][HTML] The metabolic face of migraine—from pathophysiology to treatment

EC Gross, M Lisicki, D Fischer, PS Sándor… - Nature Reviews …, 2019 - nature.com
Migraine can be regarded as a conserved, adaptive response that occurs in genetically
predisposed individuals with a mismatch between the brain's energy reserve and workload …