EGFR: An essential receptor tyrosine kinase-regulator of cancer stem cells

S Talukdar, L Emdad, SK Das, PB Fisher - Advances in cancer research, 2020 - Elsevier
Abstract The Epidermal Growth Factor Receptor (EGFR) is frequently expressed at elevated
levels in different forms of cancer and expression often correlates positively with cancer …

The Warburg effect on radioresistance: Survival beyond growth

H Kang, B Kim, J Park, HS Youn, BH Youn - Biochimica et Biophysica Acta …, 2023 - Elsevier
The Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather
than oxidative phosphorylation, even in the presence of oxygen. Although evidence of its …

Radiotherapy-induced metabolic hallmarks in the tumor microenvironment

A Mittal, M Nenwani, I Sarangi, A Achreja, TS Lawrence… - Trends in Cancer, 2022 - cell.com
Radiation is frequently administered for cancer treatment, but resistance or remission
remains common. Cancer cells alter their metabolism after radiotherapy to reduce its …

Astragaloside VI Promotes Neural Stem Cell Proliferation and Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injury via Activating EGFR …

X Chen, H Wu, H Chen, Q Wang, X Xie, J Shen - Molecular Neurobiology, 2019 - Springer
Radix Astragali (AR) is a commonly used medicinal herb for post-stroke disability in
Traditional Chinese Medicine but its active compounds for promoting neurogenic effects are …

Glutamate receptors and glioblastoma multiforme: an old “route” for new perspectives

L Corsi, A Mescola, A Alessandrini - International journal of molecular …, 2019 - mdpi.com
Glioblastoma multiforme (GBM) is the most aggressive malignant tumor of the central
nervous system, with poor survival in both treated and untreated patients. Recent studies …

Silver nanoparticle induced cytotoxicity, oxidative stress, and DNA damage in CHO cells

KK Awasthi, A Awasthi, N Kumar, P Roy… - Journal of nanoparticle …, 2013 - Springer
Abstract Silver nanoparticles (Ag NPs) are being used increasingly in wound dressings,
catheters, and in various household products due to their antimicrobial activity. The present …

Role of transcriptional corepressor CtBP1 in prostate cancer progression

R Wang, IA Asangani, BVSK Chakravarthi, B Ateeq… - Neoplasia, 2012 - Elsevier
Transcriptional repressors and corepressors play a critical role in cellular homeostasis and
are frequently altered in cancer. C-terminal binding protein 1 (CtBP1), a transcriptional …

Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors

A Ahsan, SG Ramanand, C Whitehead, SM Hiniker… - Neoplasia, 2012 - Elsevier
The epidermal growth factor receptor (EGFR) has been targeted for inhibition using tyrosine
kinase inhibitors and monoclonal antibodies, with improvement in outcome in subsets of …

EGFR targeted therapies and radiation: Optimizing efficacy by appropriate drug scheduling and patient selection

KC Cuneo, MK Nyati, D Ray, TS Lawrence - Pharmacology & therapeutics, 2015 - Elsevier
The epidermal growth factor receptor (EGFR) plays an important role in tumor progression
and treatment resistance for many types of malignancies including head and neck …

Involvement of non-coding RNAs in chemo-and radioresistance of colorectal cancer

D Fanale, M Castiglia, V Bazan, A Russo - Non-coding RNAs in Colorectal …, 2016 - Springer
Despite recent progress in understanding the cancer signaling pathways and in developing
new therapeutic strategies, however, the resistance of colorectal cancer (CRC) cells to …