Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by
prolonged hyperglycemia that leads to long-term health consequences. It is estimated that …

The claustrum is the most densely interconnected region in the human brain. Despite the
accumulating data from clinical and experimental studies, the functional role of the claustrum …

Chronic itch is a major symptom of many inflammatory skin diseases. This type of pruritus is
thought to be facilitated by cytokines that activate cutaneous nerve fibers; however, the …

Acute itch can be generated by either chemical or mechanical stimuli, which activate
separate pathways in the periphery and spinal cord. While substantial progress has been …

Our understanding of neuropathic itch is limited due to a lack of relevant animal models.
Patients with cutaneous T cell lymphoma (CTCL) experience severe itching. Here, we …

Classically, skin was considered a mere structural barrier protecting organisms from a
diversity of environmental insults. In recent decades, the cutaneous immune system has …

Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized oftentimes by
symmetrically distributed, severely pruritic nodules. Currently, the pathophysiology of PN …

Introduction to a collection. This article is intended to introduce a collection of papers on
toxic neuropathies. Toxic neuropathies can be caused by a variety of substances and by …

Neuropathic itch is clinically important but has received much less attention as compared to
neuropathic pain. In the past decade, itch-specific pathways have been characterized on a …

Background The prevalence of neuropathic pain (NP) in burn patients is reported in the
literature to be as high as 80% 1. Given the complexity of NP in burn patients and the wide …