The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

The innate immune system recognizes microbial products using germline-encoded
receptors that initiate inflammatory responses to infection. The bacterial cell wall component …

Innate immunity comprises several inflammation-related modulatory pathways which receive
signals from an array of membrane-bound and cytoplasmic pattern recognition receptors …

Administration of exogenous CDNs to activate the cGAMP-STING pathway is a promising
therapeutic strategy to unleash the full potential of cancer immunotherapy. This strategy …

The human gut is the natural habitat for trillions of microorganisms, known as the gut
microbiota, which play indispensable roles in maintaining host health. Defining the …

In all metazoans, the intestinal tract is an essential organ to integrate nutritional signaling,
hormonal cues and immunometabolic networks. The dysregulation of intestinal epithelium …

The highly contagious whooping cough agent Bordetella pertussis has evolved as a human-
restricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and …

In the Drosophila immune response, bacterial derived diaminopimelic acid-type
peptidoglycan binds the receptors PGRP-LC and PGRP-LE, which through interaction with …

Microbiota, and the plethora of signalling molecules that they generate, are a major driving
force that underlies a striking range of inter-individual physioanatomic and behavioural …

MFSD2B has been identified as the exclusive sphingosine-1-phosphate (S1P) transporter in
red blood cells (RBC) and platelets. MFSD2B-mediated S1P export from platelets is required …