[HTML][HTML] BI 456906: discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy

T Zimmermann, L Thomas, T Baader-Pagler… - Molecular …, 2022 - Elsevier
Objective Obesity and its associated comorbidities represent a global health challenge with
a need for well-tolerated, effective, and mechanistically diverse pharmaceutical …

Cross-talk of NADPH oxidases and inflammation in obesity

H Morawietz, H Brendel, P Diaba-Nuhoho, R Catar… - Antioxidants, 2023 - mdpi.com
Obesity is a major risk factor for cardiovascular and metabolic diseases. Multiple
experimental and clinical studies have shown increased oxidative stress and inflammation …

Therapeutic effects of curcumin derivatives against obesity and associated metabolic complications: a review of in vitro and in vivo studies

MT Moetlediwa, R Ramashia, C Pheiffer… - International Journal of …, 2023 - mdpi.com
Obesity is a major cause of morbidity and mortality globally, increasing the risk for chronic
diseases. Thus, the need to identify more effective anti-obesity agents has spurred …

Obesity and diabetes: the final frontier

MS Rendell - Expert Review of Endocrinology & Metabolism, 2023 - Taylor & Francis
Introduction Obesity is a key target in the treatment and prevention of diabetes and
independently to reduce the burden of cardiovascular disease. We reviewed the options …

Futile cycles: Emerging utility from apparent futility

AK Sharma, R Khandelwal, C Wolfrum - Cell Metabolism, 2024 - cell.com
Futile cycles are biological phenomena where two opposing biochemical reactions run
simultaneously, resulting in a net energy loss without appreciable productivity. Such a state …

Insights into the constellating drivers of satiety impacting dietary patterns and lifestyle

A Rakha, F Mehak, MA Shabbir, M Arslan… - Frontiers in …, 2022 - frontiersin.org
Food intake and body weight regulation are of special interest for meeting today's lifestyle
essential requirements. Since balanced energy intake and expenditure are crucial for …

Therapeutic Effects of Alisma orientale and its Active Constituents on Cardiovascular Disease and Obesity

Y Wu, X Wang, L Yang, S Kang, G Yan… - The American Journal …, 2023 - World Scientific
The treatment of cardiovascular diseases and obesity, two diseases posing a major risk to
human health, has been plagued by the scarcity of potent and effective medication with …

Is glucagon receptor activation the thermogenic solution for treating obesity?

E Conceição-Furber, T Coskun, KW Sloop… - Frontiers in …, 2022 - frontiersin.org
A major challenge of obesity therapy is to sustain clinically relevant weight loss over time.
Achieving this goal likely requires both reducing daily caloric intake and increasing caloric …

An adaptive optimized schizophrenia electroencephalogram disease prediction framework

V Gupta, A Kanungo, NK Saxena, P Kumar… - Wireless Personal …, 2023 - Springer
Electroencephalogram (EEG) signal analysis has become an interesting and required area
in the medical industry to analyze brain function for different diseases. But, the EEG signal's …

Quinoa (Chenopodium quinoa Willd.) supplemented cafeteria diet ameliorates glucose intolerance in rats

H Ozcaliskan Ilkay, D Karabulut… - Food Science & …, 2023 - Wiley Online Library
Abstract Quinoa (Chenopodium quinoa Willd.) is a pseudocereal with rich nutritional
composition, gluten free, and organoleptic. The primary aim of this study was to elucidate the …