[HTML][HTML] BI 456906: discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy
T Zimmermann, L Thomas, T Baader-Pagler… - Molecular …, 2022 - Elsevier
Objective Obesity and its associated comorbidities represent a global health challenge with
a need for well-tolerated, effective, and mechanistically diverse pharmaceutical …
a need for well-tolerated, effective, and mechanistically diverse pharmaceutical …
Cross-talk of NADPH oxidases and inflammation in obesity
H Morawietz, H Brendel, P Diaba-Nuhoho, R Catar… - Antioxidants, 2023 - mdpi.com
Obesity is a major risk factor for cardiovascular and metabolic diseases. Multiple
experimental and clinical studies have shown increased oxidative stress and inflammation …
experimental and clinical studies have shown increased oxidative stress and inflammation …
Therapeutic effects of curcumin derivatives against obesity and associated metabolic complications: a review of in vitro and in vivo studies
MT Moetlediwa, R Ramashia, C Pheiffer… - International Journal of …, 2023 - mdpi.com
Obesity is a major cause of morbidity and mortality globally, increasing the risk for chronic
diseases. Thus, the need to identify more effective anti-obesity agents has spurred …
diseases. Thus, the need to identify more effective anti-obesity agents has spurred …
Obesity and diabetes: the final frontier
MS Rendell - Expert Review of Endocrinology & Metabolism, 2023 - Taylor & Francis
Introduction Obesity is a key target in the treatment and prevention of diabetes and
independently to reduce the burden of cardiovascular disease. We reviewed the options …
independently to reduce the burden of cardiovascular disease. We reviewed the options …
Futile cycles: Emerging utility from apparent futility
AK Sharma, R Khandelwal, C Wolfrum - Cell Metabolism, 2024 - cell.com
Futile cycles are biological phenomena where two opposing biochemical reactions run
simultaneously, resulting in a net energy loss without appreciable productivity. Such a state …
simultaneously, resulting in a net energy loss without appreciable productivity. Such a state …
Insights into the constellating drivers of satiety impacting dietary patterns and lifestyle
Food intake and body weight regulation are of special interest for meeting today's lifestyle
essential requirements. Since balanced energy intake and expenditure are crucial for …
essential requirements. Since balanced energy intake and expenditure are crucial for …
Therapeutic Effects of Alisma orientale and its Active Constituents on Cardiovascular Disease and Obesity
Y Wu, X Wang, L Yang, S Kang, G Yan… - The American Journal …, 2023 - World Scientific
The treatment of cardiovascular diseases and obesity, two diseases posing a major risk to
human health, has been plagued by the scarcity of potent and effective medication with …
human health, has been plagued by the scarcity of potent and effective medication with …
Is glucagon receptor activation the thermogenic solution for treating obesity?
E Conceição-Furber, T Coskun, KW Sloop… - Frontiers in …, 2022 - frontiersin.org
A major challenge of obesity therapy is to sustain clinically relevant weight loss over time.
Achieving this goal likely requires both reducing daily caloric intake and increasing caloric …
Achieving this goal likely requires both reducing daily caloric intake and increasing caloric …
An adaptive optimized schizophrenia electroencephalogram disease prediction framework
Electroencephalogram (EEG) signal analysis has become an interesting and required area
in the medical industry to analyze brain function for different diseases. But, the EEG signal's …
in the medical industry to analyze brain function for different diseases. But, the EEG signal's …
Quinoa (Chenopodium quinoa Willd.) supplemented cafeteria diet ameliorates glucose intolerance in rats
H Ozcaliskan Ilkay, D Karabulut… - Food Science & …, 2023 - Wiley Online Library
Abstract Quinoa (Chenopodium quinoa Willd.) is a pseudocereal with rich nutritional
composition, gluten free, and organoleptic. The primary aim of this study was to elucidate the …
composition, gluten free, and organoleptic. The primary aim of this study was to elucidate the …