Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Background Whereas heart failure with reduced ejection fraction (HFrEF) is associated with
ventricular dilation and markedly reduced systolic function, heart failure with preserved …

Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …

Poor access to human left ventricular myocardium is a significant limitation in the study of
heart failure (HF). Here, we utilise a carefully procured large human heart biobank of …

Background Enhanced de-novo collagen type VI (COL VI) formation has been associated
with kidney and cardiovascular fibrosis. We hypothesized that endotrophin (ETP), a product …

Translation of cardioprotective interventions aimed at reducing myocardial injury during
ischaemia–reperfusion from experimental studies to clinical practice is an important yet …

Contraction of cardiomyocytes is dependent on sub-cellular structures called dyads, where
invaginations of the surface membrane (t-tubules) form functional junctions with the …