Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder
characterized by the progressive loss of neurons, which typically leads to severe …

Compelling evidence from basic molecular biology has demonstrated the dual roles of
microglia in the pathogenesis of Alzheimer's disease (AD). On one hand, microglia are …

Abstract Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a
global epidemic, and so far, there is neither cure nor treatment to alter its progression. The …

Alzheimer's disease (AD) is a disabling and highly prevalent neurodegenerative condition,
for which there are no effective therapies. Soluble oligomers of the amyloid-β peptide (AβOs) …

Low back pain (LBP), frequently associated with intervertebral disc (IVD) degeneration, is a
major public health concern. LBP is currently managed by pharmacological treatments and …

Current evidence suggests a central role for autophagy in Alzheimer disease (AD), and
dysfunction in the autophagic system may lead to amyloid-β (Aβ) accumulation. Using in …

Background Neuroinflammation plays a vital role in the development and maintenance of
neuropathic pain. Recent evidence has proved that bone marrow mesenchymal stem cells …

Alzheimer's disease (AD) is a progressive neurogenerative disorder manifested by gradual
memory loss and cognitive decline due to profound damage of cholinergic neurons. The …

Background Over the past few years, mesenchymal stromal cells (MSCs) have attracted a
great deal of scientific attention owing to their promising results in the treatment of incurable …

Stem cells have emerged as a potential therapy for a range of neural insults, but their
application in Alzheimer's disease (AD) is still limited and the mechanisms underlying the …