Vanadium compounds have been primarily investigated as potential therapeutic agents for
the treatment of various major health issues, including cancer, atherosclerosis, and …

Established doxorubicin cardiomyopathy is a lethal disease. When congestive heart failure
develops, mortality is approximately 50%. Extensive research has been done to understand …

Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme,
develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative …

Vanadium is a trace element, which may be beneficial and possibly essential in humans1
but certainly essential for some living organisms. 2r11 Metal ions and thus vanadium ions …

First isolated in the early 1960s, doxorubicin (DOX) remains among the most effective
anticancer drug ever developed. However, this drug has proven to be a double-edged …

Increased exposure to environmental heavy metals and metalloids and their associated
toxicities has become a major threat to human health. Hence, the association of these …

Apoptosis is an evolutionary conserved homeostatic process involved in distinct
physiological processes including organ and tissue morphogenesis, development and …

Occupational and environmental exposures to metals are associated with the development
of various cancers. Although carcinogenesis caused by metals has been intensively …

Vanadium compounds exert preventive effects against chemical carcinogenesis on animals,
by modifying, mainly, various xenobiotic enzymes, inhibiting, thus, carcinogen-derived active …

Current drug development in oncology is non-selective as it typically focuses on pathways
essential for the survival of all dividing cells. The unique metabolic profile of cancer, which is …