Quiescence is a state of reversible proliferative arrest in which cells are not actively dividing
and yet retain the capacity to reenter the cell cycle upon receiving an appropriate stimulus …

The mammalian ovary has two main functions—producing mature oocytes for fertilization
and secreting hormones for maintaining the ovarian endocrine functions. Both functions are …

Cyclophosphamide and doxorubicin lead to premature ovarian insufficiency as an off-target
effect. However, their oocyte death pathway has been debated. Here, we clarified the …

Mammalian ovaries consist of follicles as basic functional units. Each follicle comprised an
innermost oocyte and several surrounding flattened granulosa cells. Unlike males …

Background Cryopreservation and transplantation of ovarian tissue (OTCTP) represent a
promising fertility preservation technique for prepubertal patients or for patients requiring …

Premature ovarian insufficiency (POI) is characterized by symptoms caused by ovarian
dysfunction in patients aged< 40 years. It is associated with a shortened reproductive …

Abstract Ethnopharmacological relevance Zigui-Yichong-Fang (ZGYCF) is a traditional
Chinese medicine prescription for the treatment of infertility and premature ovarian …

Cryopreservation and transplantation of ovarian tissue represent a promising fertility
preservation technique for prepubertal patients or for patients requiring urgent oncological …

Background 4-vinylcyclohexene diepoxide (VCD) has long been considered a hazardous
occupational chemical that promotes ovarian failure. However, VCD is also used as a …

Doxorubicin (DOX) has dose-dependent toxicity on ovarian follicles (OFs), and the inhibition
of different signaling molecules along with the DOX application for enhancing its efficacy can …