Combating mosquito-borne diseases using genetic control technologies
Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …
burdens. Unfortunately, current control methods based on insecticides and environmental …
Vector biology meets disease control: using basic research to fight vector-borne diseases
WR Shaw, F Catteruccia - Nature microbiology, 2019 - nature.com
Human pathogens that are transmitted by insects are a global problem, particularly those
vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species …
vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species …
Development of a confinable gene drive system in the human disease vector Aedes aegypti
Aedes aegypti is the principal mosquito vector for many arboviruses that increasingly infect
millions of people every year. With an escalating burden of infections and the relative failure …
millions of people every year. With an escalating burden of infections and the relative failure …
Targeted delivery of CRISPR-Cas9 ribonucleoprotein into arthropod ovaries for heritable germline gene editing
Cas9-mediated gene editing is a powerful tool for addressing research questions in
arthropods. Current approaches rely upon delivering Cas9 ribonucleoprotein (RNP) …
arthropods. Current approaches rely upon delivering Cas9 ribonucleoprotein (RNP) …
Transforming insect population control with precision guided sterile males with demonstration in flies
The sterile insect technique (SIT) is an environmentally safe and proven technology to
suppress wild populations. To further advance its utility, a novel CRISPR-based technology …
suppress wild populations. To further advance its utility, a novel CRISPR-based technology …
Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements
MAE Anderson, E Gonzalez, JXD Ang… - Nature …, 2023 - nature.com
CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to
mosquito control. While attempts have been made to develop such systems in Aedes …
mosquito control. While attempts have been made to develop such systems in Aedes …
Aedes aegypti Argonaute 2 controls arbovirus infection and host mortality
S Dong, G Dimopoulos - Nature communications, 2023 - nature.com
Ae. aegypti mosquitoes transmit some of the most important human viral diseases that are
responsible for a significant public health burden worldwide. The small interfering RNA …
responsible for a significant public health burden worldwide. The small interfering RNA …
Humidity sensors that alert mosquitoes to nearby hosts and egg-laying sites
To reproduce and to transmit disease, female mosquitoes must obtain blood meals and
locate appropriate sites for egg laying (oviposition). While distinct sensory cues drive each …
locate appropriate sites for egg laying (oviposition). While distinct sensory cues drive each …
Challenges and opportunities in controlling mosquito-borne infections
NM Ferguson - Nature, 2018 - nature.com
Mosquito-borne diseases remain a major cause of morbidity and mortality across the tropical
regions. Despite much progress in the control of malaria, malaria-associated morbidity …
regions. Despite much progress in the control of malaria, malaria-associated morbidity …
How to turn an organism into a model organism in 10 'easy'steps
BJ Matthews, LB Vosshall - Journal of Experimental Biology, 2020 - journals.biologists.com
Many of the major biological discoveries of the 20th century were made using just six
species: Escherichia coli bacteria, Saccharomyces cerevisiae and Schizosaccharomyces …
species: Escherichia coli bacteria, Saccharomyces cerevisiae and Schizosaccharomyces …