Combating mosquito-borne diseases using genetic control technologies

GH Wang, S Gamez, RR Raban, JM Marshall… - Nature …, 2021 - nature.com
Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Vector biology meets disease control: using basic research to fight vector-borne diseases

WR Shaw, F Catteruccia - Nature microbiology, 2019 - nature.com
Human pathogens that are transmitted by insects are a global problem, particularly those
vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species …

Development of a confinable gene drive system in the human disease vector Aedes aegypti

M Li, T Yang, NP Kandul, M Bui, S Gamez, R Raban… - Elife, 2020 - elifesciences.org
Aedes aegypti is the principal mosquito vector for many arboviruses that increasingly infect
millions of people every year. With an escalating burden of infections and the relative failure …

Targeted delivery of CRISPR-Cas9 ribonucleoprotein into arthropod ovaries for heritable germline gene editing

D Chaverra-Rodriguez, VM Macias, GL Hughes… - Nature …, 2018 - nature.com
Cas9-mediated gene editing is a powerful tool for addressing research questions in
arthropods. Current approaches rely upon delivering Cas9 ribonucleoprotein (RNP) …

Transforming insect population control with precision guided sterile males with demonstration in flies

NP Kandul, J Liu, HM Sanchez C, SL Wu… - Nature …, 2019 - nature.com
The sterile insect technique (SIT) is an environmentally safe and proven technology to
suppress wild populations. To further advance its utility, a novel CRISPR-based technology …

Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements

MAE Anderson, E Gonzalez, JXD Ang… - Nature …, 2023 - nature.com
CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to
mosquito control. While attempts have been made to develop such systems in Aedes …

Aedes aegypti Argonaute 2 controls arbovirus infection and host mortality

S Dong, G Dimopoulos - Nature communications, 2023 - nature.com
Ae. aegypti mosquitoes transmit some of the most important human viral diseases that are
responsible for a significant public health burden worldwide. The small interfering RNA …

Humidity sensors that alert mosquitoes to nearby hosts and egg-laying sites

WJ Laursen, G Budelli, R Tang, EC Chang, R Busby… - Neuron, 2023 - cell.com
To reproduce and to transmit disease, female mosquitoes must obtain blood meals and
locate appropriate sites for egg laying (oviposition). While distinct sensory cues drive each …

Challenges and opportunities in controlling mosquito-borne infections

NM Ferguson - Nature, 2018 - nature.com
Mosquito-borne diseases remain a major cause of morbidity and mortality across the tropical
regions. Despite much progress in the control of malaria, malaria-associated morbidity …

How to turn an organism into a model organism in 10 'easy'steps

BJ Matthews, LB Vosshall - Journal of Experimental Biology, 2020 - journals.biologists.com
Many of the major biological discoveries of the 20th century were made using just six
species: Escherichia coli bacteria, Saccharomyces cerevisiae and Schizosaccharomyces …