Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by
the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential …

Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …

Increasing evidence indicates a possible causal link between neuroinflammation and
neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Parkinson's disease (PD) occurs in approximately 1% of the population over 65 years of age
and has become increasingly more common with advances in age. The number of …

A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

Measurements of hepatic iron concentration (HIC) are important predictors of transfusional
iron burden and long-term outcome in patients with transfusion-dependent anemias. The …

For the last century, there has been great physiological interest in brain iron and its role in
brain function and disease. It is well known that iron accumulates in the brain for people with …

Purpose To evaluate the sensitivity and specificity of quantitative magnetic resonance (MR)
iron mapping including R2, R2* and magnetic susceptibility to differentiate patients with …

Iron and its homeostasis are intimately tied to the inflammatory response. The adaptation to
iron deficiency, which confers resistance to infection and improves the inflammatory …

One objective of modern neuroimaging is to identify markers that can aid in diagnosis,
disease progression monitoring and long-term drug impact analysis. In this study, Parkinson …