The prefrontal cortex (PFC) supports decision-making, goal tracking, and planning. Spatial
navigation is a behavior that taxes these cognitive processes, yet the role of the PFC in …

It is widely believed that memories that are encoded and retrieved during waking behavior
are consolidated during sleep. Recent studies on the interactions between the hippocampus …

Active navigation seems to yield better spatial knowledge than passive navigation, but it is
unclear how active decision-making influences learning and memory. Here, we examined …

The ability to learn novel items depends on brain functions that store information about items
classified by their associated meanings and outcomes,,–, but the underlying neural circuit …

Spatial navigation involves multiple cognitive processes including multisensory integration,
visuospatial coding, memory, and decision-making. These functions are mediated by the …

Older adults have difficulties in navigating unfamiliar environments and updating their
wayfinding behavior when faced with blocked routes. This decline in navigational …

Spatial learning can be based on intramaze cues and environmental boundaries. These
processes are predominantly subserved by striatal-and hippocampal-dependent circuitries …

Normal aging is typically associated with declines in navigation and spatial memory abilities.
However, increased interindividual variability in performance across various …

Navigation waxes and wanes in precision and flexibility over the life span. However, at no
age is it completely egocentric or allocentric, or completely nonmetric. Instead, we see …

Experiments on rodents have demonstrated that transecting the white matter fibre pathway
linking the hippocampus with an array of cortical and subcortical structures-the fornix …