The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases
Cardiometabolic diseases encompass a range of interrelated conditions that arise from
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
[HTML][HTML] Associations of air pollution with COVID-19 positivity, hospitalisations, and mortality: observational evidence from UK Biobank
Individual-level studies with adjustment for important COVID-19 risk factors suggest positive
associations of long-term air pollution exposure (particulate matter and nitrogen dioxide) …
associations of long-term air pollution exposure (particulate matter and nitrogen dioxide) …
Frailty in individuals with depression, bipolar disorder and anxiety disorders: longitudinal analyses of all-cause mortality
Background Frailty is a medical syndrome that is strongly associated with mortality risk and
an emerging global health burden. Mental disorders are associated with reduced life …
an emerging global health burden. Mental disorders are associated with reduced life …
Cardiovascular health, infection burden and their interactive association with brain volumetric and white matter integrity outcomes in the UK Biobank
Background Cardiovascular health is associated with brain magnetic resonance imaging
(MRI) markers of pathology and infections may modulate this association. Methods Using …
(MRI) markers of pathology and infections may modulate this association. Methods Using …
[HTML][HTML] Psychological factors substantially contribute to biological aging: evidence from the aging rate in Chinese older adults
We have developed a deep learning aging clock using blood test data from the China
Health and Retirement Longitudinal Study, which has a mean absolute error of 5.68 years …
Health and Retirement Longitudinal Study, which has a mean absolute error of 5.68 years …
Why do we care more about disease than health?
M Picard - Phenomics, 2022 - Springer
Modern Western biomedical research and clinical practice are primarily focused on disease.
This disease-centric approach has yielded an impressive amount of knowledge around what …
This disease-centric approach has yielded an impressive amount of knowledge around what …
Biological age estimation using circulating blood biomarkers
J Bortz, A Guariglia, L Klaric, D Tang, P Ward… - Communications …, 2023 - nature.com
Biological age captures physiological deterioration better than chronological age and is
amenable to interventions. Blood-based biomarkers have been identified as suitable …
amenable to interventions. Blood-based biomarkers have been identified as suitable …
Associations between air pollution and multimorbidity in the UK Biobank: A cross-sectional study
A Ronaldson, J Arias de la Torre, M Ashworth… - Frontiers in Public …, 2022 - frontiersin.org
Background Long-term exposure to air pollution concentrations is known to be adversely
associated with a broad range of single non-communicable diseases, but its role in …
associated with a broad range of single non-communicable diseases, but its role in …
Sex hormones and the risk of myocardial infarction in women and men: a prospective cohort study in the UK Biobank
K Harris, SAE Peters, M Woodward - Biology of sex Differences, 2023 - Springer
Objectives There is conflicting evidence around the role of sex hormones with
cardiovascular outcomes. The aim of this study was to examine the association of sex …
cardiovascular outcomes. The aim of this study was to examine the association of sex …
Cross-classification between self-rated health and health status: longitudinal analyses of all-cause mortality and leading causes of death in the UK
Risk stratification is an important public health priority that is central to clinical decision
making and resource allocation. The aim of this study was to examine how different …
making and resource allocation. The aim of this study was to examine how different …