Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets
T Wang, C Gross, AA Desai… - … of Physiology-Lung …, 2017 - journals.physiology.org
Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory
failure due to acute respiratory distress syndrome (ARDS). Paradoxically, mechanical …
failure due to acute respiratory distress syndrome (ARDS). Paradoxically, mechanical …
Non-canonical dimerization of the androgen receptor and other nuclear receptors: implications for human disease
A Jiménez-Panizo, P Pérez, AM Rojas… - Endocrine-Related …, 2019 - erc.bioscientifica.com
Nuclear receptors are transcription factors that play critical roles in development,
homeostasis and metabolism in all multicellular organisms. An important family of nuclear …
homeostasis and metabolism in all multicellular organisms. An important family of nuclear …
[HTML][HTML] Effects of ginsenoside Rb1 on oxidative stress injury in rat spinal cords by regulating the eNOS/Nrf2/HO‑1 signaling pathway
X Liu, X Gu, M Yu, Y Zi, H Yu… - Experimental and …, 2018 - spandidos-publications.com
The present study aimed to investigate whether ginsenoside Rb1 (G‑Rb1) attenuates spinal
cord injury‑associated oxidative stress in rats by regulating the endothelial nitric oxide …
cord injury‑associated oxidative stress in rats by regulating the endothelial nitric oxide …
[PDF][PDF] Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target
The 90 kDa heat-shock protein (Hsp90) is an abundant molecular chaperone that is
essential to activate, stabilize and regulate the function of a plethora of client proteins. As …
essential to activate, stabilize and regulate the function of a plethora of client proteins. As …
Harnessing the heterogeneity of prostate cancer for target discovery using patient-derived explants
MM Centenera, AD Vincent, M Moldovan, HM Lin… - Cancers, 2022 - mdpi.com
Simple Summary There is a widespread push toward more biologically relevant pre-clinical
models of prostate cancer that can improve the discovery and translation of new drugs and …
models of prostate cancer that can improve the discovery and translation of new drugs and …
Synthesis and Biological Activity of 3-(Heteroaryl)quinolin-2(1H)-ones Bis-Heterocycles as Potential Inhibitors of the Protein Folding Machinery Hsp90
EL Larghi, A Bruneau, F Sauvage, M Alami… - Molecules, 2022 - mdpi.com
In the context of our SAR study concerning 6BrCaQ analogues as C-terminal Hsp90
inhibitors, we designed and synthesized a novel series of 3-(heteroaryl) quinolin-2 (1 H), of …
inhibitors, we designed and synthesized a novel series of 3-(heteroaryl) quinolin-2 (1 H), of …
[HTML][HTML] Therapeutic and vaccinomic potential of moonlighting proteins for the discovery and design of drugs and vaccines against schistosomiasis
K Motlhatlhedi, NB Pilusa, T Ndaba… - American Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Despite significant and coordinated efforts to combat schistosomiasis, such as providing
clean water, sanitation, hygiene, and snail control, these strategies still fall short, as regions …
clean water, sanitation, hygiene, and snail control, these strategies still fall short, as regions …
[PDF][PDF] Crystal structure of the middle and C-terminal domains of Hsp90a labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target
The 90 kDa heat-shock protein (Hsp90) is an abundant molecular chaperone that is
essential to activate, stabilize and regulate the function of a plethora of client proteins. As …
essential to activate, stabilize and regulate the function of a plethora of client proteins. As …
Total Synthesis of the Reported Structure of Stresgenin B, its Structural Elucidation Using DFT Calculations, and Visible-Light-Mediated Functionalizations of Electron …
WC Chan - 2020 - search.proquest.com
The first chapter outlines the synthesis of the reported structure of stresgenin B. Stresgenin B
was reported to be small molecule inhibitor of heat shock proteins (HSPs). Toward this …
was reported to be small molecule inhibitor of heat shock proteins (HSPs). Toward this …