Personalized therapy for mycophenolate: consensus report by the international association of therapeutic drug monitoring and clinical toxicology

S Bergan, M Brunet, DA Hesselink… - Therapeutic drug …, 2021 - journals.lww.com
When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy,
fixed doses were recommended by the manufacturer. Awareness of the potential for a more …

Prevention of complications from use of conventional immunosuppressants: a critical review

C Ponticelli, RJ Glassock - Journal of nephrology, 2019 - Springer
Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and
in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that …

Therapeutic drug monitoring of mycophenolate mofetil in pediatric patients: novel techniques and current opinion

R Ehren, AM Schijvens, A Hackl… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Mycophenolate mofetil (MMF) is an ester prodrug of the immunosuppressant
mycophenolic acid (MPA) and is recommended and widely used for maintenance …

Effect of UGT polymorphisms on pharmacokinetics and adverse reactions of mycophenolic acid in kidney transplant patients

Z Jiang, N Hu - Pharmacogenomics, 2021 - Taylor & Francis
Mycophenolic acid (MPA) is a common immunosuppressive drug for kidney transplantation
patients, and is characterized by a narrow therapeutic index and significant individual …

[PDF][PDF] Mycophenolic acid pharmacogenomics in kidney transplantation

FDV Genvigir, A Cerda, TDC Hirata… - Journal of …, 2020 - repositorio.usp.br
Mycophenolic acid (MPA) is a potent antiproliferative drug prescribed to prevent acute
rejection in kidney transplantation. MPA reversibly inhibits the enzymes involved in the …

Fortification of biscuit with sidr leaf and flaxseed mitigates immunosuppression and nephrotoxicity induced by cyclosporine A

GM El Seedy, ES El‐Shafey… - Journal of Food …, 2021 - Wiley Online Library
The focus of consumers in healthy food turned to the possible health benefits of particular
foods and food ingredients. This study aimed to evaluate the newly fortified biscuits …

Genetic variants associated with immunosuppressant pharmacokinetics and adverse effects in the DeKAF genomics genome-wide association studies

WS Oetting, B Wu, DP Schladt, W Guan… - …, 2019 - journals.lww.com
Background. The immunosuppressants tacrolimus and mycophenolate are important
components to the success of organ transplantation, but are also associated with adverse …

Influence of SLCO1B1 521T> C, UGT2B7 802C> T and IMPDH1− 106G> A genetic polymorphisms on mycophenolic acid levels and adverse reactions in chinese …

Q Shu, Q Fan, B Hua, H Liu, S Wang, Y Liu… - Pharmacogenomics …, 2021 - Taylor & Francis
Introduction Mycophenolate mofetil (MMF), a new type of immunosuppressant, has emerged
as a frontline agent for treating autoimmune diseases. Mycophenolic acid (MPA) is an active …

[HTML][HTML] A GC–MS-based untargeted metabolomics approach for comprehensive metabolic profiling of mycophenolate mofetil-induced toxicity in mice

T Zhao, Y Zhao, H Chen, W Sun… - Frontiers in Molecular …, 2024 - frontiersin.org
Background: Mycophenolate mofetil (MMF), the morpholinoethyl ester of mycophenolic acid,
is widely used for maintenance immunosuppression in transplantation. The gastrointestinal …

Influence of genetic polymorphisms on pharmacokinetics and treatment response of mycophenolic acid: a scoping review

HY Yow, M Ikawati, S Siswanto, A Hermawan… - …, 2024 - Taylor & Francis
This scoping review explores the impact of genetic polymorphisms on the pharmacokinetics
and treatment responses of mycophenolic acid (MPA), an immunosuppressant. The study …