Abstract 'Every Hour Hurts, The Last One Kills'. That is an old saying about getting old. Every
day, thousands of DNA damaging events take place in each cell of our body, but efficient …

Uterine leiomyosarcoma (u‐LMS) and endometrial stromal sarcoma (ESS) are among the
most frequent soft tissue sarcomas, which, in adults, lead to fatal lung metastases and …

We characterized the initiation and evolution of the immune response against a new
inducible p53-dependent model of aggressive ovarian carcinoma that recapitulates the …

Purpose: We examined whether prospective molecular characterization of advanced
metastatic disease can reveal grade and/or histology-specific differences to inform diagnosis …

DNA repair represents the first barrier against genotoxic stress causing metabolic changes,
inflammation and cancer. Besides its role in preventing cancer, DNA repair needs also to be …

Background Soft‐tissue sarcomas (STS) describe a heterogeneous group of mesenchymal
tumors with limited treatment options. Targeted therapies exist for BRCA1/2 gene alterations …

Uterine sarcoma is a rare neoplasm, accounting for only 5% of uterine malignancies. The
pathogenesis of uterine sarcoma remains largely unknown, although recent basic science …

Purpose: A preliminary study performed on a small cohort of multifocal prostate cancer
(PCa) detected BRCA1 allelic imbalances among circulating tumor cells (CTC). The present …

Ovarian cancer is a complex and deadly disease that remains difficult to detect at an early
curable stage. Furthermore, although some oncogenic (Kras, Pten/PI3K and Trp53) …

Purpose: Uterine leiomyosarcoma (ULMS) is a poorly understood cancer with few effective
treatments. This study explores the molecular events involved in ULMS with the goal of …