ADP-ribosylation from molecular mechanisms to therapeutic implications
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
(ADP-ribosyl) hydrolases: structure, function, and biology
ADP-ribosylation is an intricate and versatile posttranslational modification involved in the
regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives …
regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives …
Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling
EJ Longarini, H Dauben, C Locatelli, AR Wondisford… - Molecular Cell, 2023 - cell.com
PARP1, an established anti-cancer target that regulates many cellular pathways, including
DNA repair signaling, has been intensely studied for decades as a poly (ADP-ribosyl) …
DNA repair signaling, has been intensely studied for decades as a poly (ADP-ribosyl) …
Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling
In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial
importance to mark sites of DNA damage as well as recruit and regulate repairs factors …
importance to mark sites of DNA damage as well as recruit and regulate repairs factors …
An HPF1/PARP1-based chemical biology strategy for exploring ADP-ribosylation
JJ Bonfiglio, O Leidecker, H Dauben, EJ Longarini… - Cell, 2020 - cell.com
Strategies for installing authentic ADP-ribosylation (ADPr) at desired positions are
fundamental for creating the tools needed to explore this elusive post-translational …
fundamental for creating the tools needed to explore this elusive post-translational …
ADP-ribosylation of RNA and DNA: from in vitro characterization to in vivo function
L Weixler, K Schäringer, J Momoh… - Nucleic acids …, 2021 - academic.oup.com
The functionality of DNA, RNA and proteins is altered dynamically in response to
physiological and pathological cues, partly achieved by their modification. While the …
physiological and pathological cues, partly achieved by their modification. While the …
Mechanistic insights into the three steps of poly (ADP-ribosylation) reversal
Abstract Poly (ADP-ribosyl) ation (PAR) is a versatile and complex posttranslational
modification composed of repeating units of ADP-ribose arranged into linear or branched …
modification composed of repeating units of ADP-ribose arranged into linear or branched …
Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation
AK Hopp, P Grüter, MO Hottiger - Cells, 2019 - mdpi.com
Cells constantly adapt their metabolic pathways to meet their energy needs and respond to
nutrient availability. During the last two decades, it has become increasingly clear that …
nutrient availability. During the last two decades, it has become increasingly clear that …
Why structure and chain length matter: on the biological significance underlying the structural heterogeneity of poly (ADP-ribose)
JM Reber, A Mangerich - Nucleic Acids Research, 2021 - academic.oup.com
Abstract Poly (ADP-ribosyl) ation (PARylation) is a multifaceted post-translational
modification, carried out by poly (ADP-ribosyl) transferases (poly-ARTs, PARPs), which play …
modification, carried out by poly (ADP-ribosyl) transferases (poly-ARTs, PARPs), which play …
ADP-ribosylation signalling and human disease
ADP-ribosylation (ADPr) is a reversible post-translational modification of proteins, which
controls major cellular and biological processes, including DNA damage repair, cell …
controls major cellular and biological processes, including DNA damage repair, cell …