Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

The adoptive transfer of T cells that are engineered to express chimeric antigen receptors
(CARs) has shown remarkable success in treating B cell malignancies but only limited …

Tumors are one of the main causes of death in humans. The development of safe and
effective methods for early diagnosis and treatment of tumors is a difficult problem that needs …

The tumor microenvironment (TME) has been identified as one of the driving factors of tumor
progression and invasion. Within this microenvironment, cancer‐associated fibroblasts …

Simple Summary Tumors are not masses of cancer cells alone but made up of cancer cells,
other cells including fibroblasts, macrophages, endothelial cells, as well as secreted factors …

CXC motif chemokine receptor 7 (CXCR7) is a newly discovered atypical chemokine
receptor that binds to CXC motif chemokine ligand 12 (CXCL12) with higher affinity than …

Determining mechanisms of resistance to αPD-1/PD-L1 immune-checkpoint immunotherapy
is key to developing new treatment strategies. Cancer-associated fibroblasts (CAF) have …

The nature and extent of immune cell infiltration into solid tumours are key determinants of
therapeutic response. Here, using a DNA methylation-based approach to tumour cell …

Fibroblasts are poorly characterised cells that variably impact tumour progression. Here, we
use single cell RNA-sequencing, multiplexed immunohistochemistry and digital cytometry …