Traumatic brain injury (TBI) is a major medical and socio-economic problem, and is the
leading cause of death in children and young adults. The critical care management of …

Near-infrared spectroscopy (NIRS) has potential as a noninvasive brain monitor across a
spectrum of disorders. In the last decade, there has been a rapid expansion of clinical …

This report is the second part of a comprehensive two-part series aimed at reviewing an
extensive and diverse toolkit of novel methods to explore brain health and function. While …

Cerebral blood flow (CBF) and cerebral autoregulation (CA) are critically important to
maintain proper brain perfusion and supply the brain with the necessary oxygen and energy …

Multi-modal biomarkers (eg, imaging, blood-based, physiological) of unique traumatic brain
injury (TBI) endophenotypes are necessary to guide the development of personalized and …

Adequate oxygen delivery to a tissue depends on sufficient oxygen content in arterial blood
and blood flow to the tissue. Oximetry is a technique for the assessment of blood …

Capabilities in real-time monitoring of internal physiological processes could inform
pharmacological drug-delivery schedules, surgical intervention procedures and the …

Traumatic brain injury (TBI) occurs when a sudden trauma causes damage to the brain. TBI
can result when the head suddenly and violently impacts an object or when an object …

Cerebral near-infrared spectroscopy (NIRS) has long represented an exciting prospect for
the noninvasive monitoring of cerebral tissue oxygenation and perfusion in the context of …

Rapid detection of ischemic conditions at the bedside can improve treatment of acute brain
injury. In this observational study of 11 critically ill brain-injured adults, we employed a …