[HTML][HTML] The foundation and architecture of precision medicine in neurology and psychiatry
Neurological and psychiatric diseases have high degrees of genetic and pathophysiological
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
Brain imaging genomics: integrated analysis and machine learning
L Shen, PM Thompson - Proceedings of the IEEE, 2019 - ieeexplore.ieee.org
Brain imaging genomics is an emerging data science field, where integrated analysis of
brain imaging and genomics data, often combined with other biomarker, clinical, and …
brain imaging and genomics data, often combined with other biomarker, clinical, and …
A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics
H Lu, J Qiao, Z Shao, T Wang, S Huang, P Zeng - BMC medicine, 2021 - Springer
Background Recent genome-wide association studies (GWASs) have revealed the
polygenic nature of psychiatric disorders and discovered a few of single-nucleotide …
polygenic nature of psychiatric disorders and discovered a few of single-nucleotide …
What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group
MRI‐derived brain measures offer a link between genes, the environment and behavior and
have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of …
have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of …
Genetics and brain transcriptomics of completed suicide
Objective: The authors sought to study the transcriptomic and genomic features of completed
suicide by parsing the method chosen, to capture molecular correlates of the distinctive …
suicide by parsing the method chosen, to capture molecular correlates of the distinctive …
The genome-wide risk alleles for psychiatric disorders at 3p21. 1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine
Z Yang, D Zhou, H Li, X Cai, W Liu, L Wang… - Molecular …, 2020 - nature.com
Schizophrenia and bipolar disorder (BPD) are believed to share clinical features, etiological
factors, and disease pathologies (such as impaired cognitive functions and dendritic spine …
factors, and disease pathologies (such as impaired cognitive functions and dendritic spine …
Effects of copy number variations on brain structure and risk for psychiatric illness: Large‐scale studies from the ENIGMA working groups on CNVs
Abstract The Enhancing NeuroImaging Genetics through Meta‐Analysis copy number
variant (ENIGMA‐CNV) and 22q11. 2 Deletion Syndrome Working Groups (22q‐ENIGMA …
variant (ENIGMA‐CNV) and 22q11. 2 Deletion Syndrome Working Groups (22q‐ENIGMA …
Genome-wide association study of musical beat synchronization demonstrates high polygenicity
M Niarchou, DE Gustavson… - Nature Human …, 2022 - nature.com
Moving in synchrony to the beat is a fundamental component of musicality. Here we
conducted a genome-wide association study to identify common genetic variants associated …
conducted a genome-wide association study to identify common genetic variants associated …
The potential role of dysfunctions in neuron-microglia communication in the pathogenesis of brain disorders
K Chamera, E Trojan… - Current …, 2020 - ingentaconnect.com
The bidirectional communication between neurons and microglia is fundamental for the
proper functioning of the central nervous system (CNS). Chemokines and clusters of …
proper functioning of the central nervous system (CNS). Chemokines and clusters of …