Engagement of antigen-specific T cell receptors (TCRs) is a prerequisite for T cell activation.
Acquisition of appropriate effector T cell function requires the participation of multiple signals …

T cells are critically important for host defense against infections. T cell activation is specific
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …

The gut microbiome plays a central role in inflammatory bowel diseases (IBDs)
pathogenesis and propagation. To determine whether the gut microbiome may predict …

Investigators have made key advances in rheumatoid arthritis (RA) genetics in the past 10
years. Although genetic studies have had limited influence on clinical practice and drug …

The NCI-60 cell line collection is a very widely used panel for the study of cellular
mechanisms of cancer in general and in vitro drug action in particular. It is a model system …

Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …

The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and
for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly …

PTPN22 encodes a tyrosine phosphatase that is expressed by haematopoietic cells and
functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signalling …

Systemic Lupus Erythematosus (SLE) is characterized by a wide spectrum of auto-
antibodies which recognize several cellular components. The production of these self …

A major advance in adoptive T‐cell therapy (ACT) is the ability to efficiently endow patient's
T cells with reactivity for tumor antigens through the stable or regulated introduction of genes …