Comparative evaluation of recombinant protein production in different biofactories: the green perspective
M Merlin, E Gecchele, S Capaldi… - BioMed research …, 2014 - Wiley Online Library
In recent years, the production of recombinant pharmaceutical proteins in heterologous
systems has increased significantly. Most applications involve complex proteins and …
systems has increased significantly. Most applications involve complex proteins and …
Broadly neutralizing antibodies targeting HIV: Progress and challenges
Anti-HIV broadly neutralizing antibodies (bNAbs) offer a novel approach to treating,
preventing, or curing HIV. Pre-clinical models and clinical trials involving the passive transfer …
preventing, or curing HIV. Pre-clinical models and clinical trials involving the passive transfer …
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
Passive immunization with HIV-1–neutralizing monoclonal antibodies (mAbs) is being
considered for prevention and treatment of HIV-1 infection. As therapeutic agents, mAbs …
considered for prevention and treatment of HIV-1 infection. As therapeutic agents, mAbs …
Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults
Clinical & Experimental Immunology, 2015 - academic.oup.com
Summary VRC-HIVMAB060-00-AB (VRC01) is a broadly neutralizing HIV-1 monoclonal
antibody (mAb) isolated from the B cells of an HIV-infected patient. It is directed against the …
antibody (mAb) isolated from the B cells of an HIV-infected patient. It is directed against the …
Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
To determine the protective potential of the humoral immune response against HIV-1 in vivo
we evaluated the potency of three neutralizing antibodies (2G12, 2F5 and 4E10) in …
we evaluated the potency of three neutralizing antibodies (2G12, 2F5 and 4E10) in …
Engineering of Pichia pastoris for improved production of antibody fragments
The methylotrophic yeast Pichia pastoris has been used for the expression of many proteins,
including antibody fragments. However, limitations became obvious especially when …
including antibody fragments. However, limitations became obvious especially when …
From gene to harvest: insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants
M Sack, T Rademacher, H Spiegel… - Plant biotechnology …, 2015 - Wiley Online Library
Summary The EU Sixth Framework Programme Integrated Project 'Pharma‐
Planta'developed an approved manufacturing process for recombinant plant‐made …
Planta'developed an approved manufacturing process for recombinant plant‐made …
Broadly neutralizing antibodies for HIV eradication
KE Stephenson, DH Barouch - Current Hiv/aids Reports, 2016 - Springer
Passive transfer of antibodies has long been considered a potential treatment modality for
infectious diseases, including HIV. Early efforts to use antibodies to suppress HIV …
infectious diseases, including HIV. Early efforts to use antibodies to suppress HIV …
Antibody-mediated prevention and treatment of HIV-1 infection
H Gruell, F Klein - Retrovirology, 2018 - Springer
Novel broadly neutralizing antibodies targeting HIV-1 hold promise for their use in the
prevention and treatment of HIV-1 infection. Pre-clinical results have encouraged the …
prevention and treatment of HIV-1 infection. Pre-clinical results have encouraged the …
Cost-effective production of a vaginal protein microbicide to prevent HIV transmission
K Ramessar, T Rademacher, M Sack… - Proceedings of the …, 2008 - National Acad Sciences
A series of small-molecule microbicides has been developed for vaginal delivery to prevent
heterosexual HIV transmission, but results from human clinical trials have been …
heterosexual HIV transmission, but results from human clinical trials have been …