The last 40 years have witnessed how p53 rose from a viral binding protein to a central
factor in both stress responses and tumor suppression. The exquisite regulation of p53 …

Somatic mutations in the TP53 gene are one of the most frequent alterations in human
cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which …

Ferroptosis, a novel form of regulated cell death induced by iron-dependent lipid
peroxidation, plays an essential role in the development and drug resistance of tumors …

A nonsynonymous single-nucleotide polymorphism at codon 47 in TP53 exists in African-
descent populations (P47S, rs1800371; referred to here as S47). Here we report that, in …

The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

Pancreatic cancer (PC) is a serious malignancy with high mortality and poor prognosis due
to nonspecific incipient symptoms and early metastasis. Also, increasing evidence indicates …

Thirty years of research on the p53 family of genes has generated almost fifty thousand
publications. The first of these papers detected the p53 protein associated with a viral …

Background This open-label, first-in-human, phase 1 study evaluated AMG 232, an oral
selective MDM2 inhibitor in patients with TP53 wild-type (P53WT), advanced solid tumors or …

Decades of research have shown that mutations in the p53 stress response pathway affect
the incidence of diverse cancers more than mutations in other pathways. However, most …

P53 is known as the most critical tumor suppressor and is often referred to as the guardian of
our genome. More than 40 years after its discovery, we are still struggling to understand all …