Molecular changes and signaling events occurring in spermatozoa during epididymal maturation

MG Gervasi, PE Visconti - Andrology, 2017 - Wiley Online Library
After leaving the testis, spermatozoa have not yet acquired the ability to move progressively
and are unable to fertilize oocytes. To become fertilization competent, they must go through …

Contribution of epididymal epithelial cell functions to sperm epigenetic changes and the health of progeny

H Chen, MBR Alves… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Spermatozoa acquire their motility and fertilizing abilities during their
maturation through the epididymis. This process is controlled by epididymal epithelial cells …

m6A-dependent biogenesis of circular RNAs in male germ cells

C Tang, Y Xie, T Yu, N Liu, Z Wang, RJ Woolsey… - Cell Research, 2020 - nature.com
The majority of circular RNAs (circRNAs) spliced from coding genes contain open reading
frames (ORFs) and thus, have protein coding potential. However, it remains unknown what …

Oviductal motile cilia are essential for oocyte pickup but dispensable for sperm and embryo transport

S Yuan, Z Wang, H Peng, SM Ward… - Proceedings of the …, 2021 - National Acad Sciences
Mammalian oviducts play an essential role in female fertility by picking up ovulated oocytes
and transporting and nurturing gametes (sperm/oocytes) and early embryos. However, the …

Spata6 is required for normal assembly of the sperm connecting piece and tight head–tail conjunction

S Yuan, CJ Stratton, J Bao, H Zheng… - Proceedings of the …, 2015 - National Acad Sciences
“Pinhead sperm,” or “acephalic sperm,” a type of human teratozoospermia, refers to the
condition in which ejaculate contains mostly sperm flagella without heads. Family clustering …

mir-34b/c and mir-449a/b/c are required for spermatogenesis, but not for the first cleavage division in mice

S Yuan, C Tang, Y Zhang, J Wu, J Bao… - Biology …, 2015 - journals.biologists.com
Mammalian sperm are carriers of not only the paternal genome, but also the paternal
epigenome in the forms of DNA methylation, retained histones and noncoding RNAs …

Motile cilia of the male reproductive system require miR-34/miR-449 for development and function to generate luminal turbulence

S Yuan, Y Liu, H Peng, C Tang… - Proceedings of the …, 2019 - National Acad Sciences
Cilia are cell-surface, microtubule-based organelles that project into extracellular space.
Motile cilia are conserved throughout eukaryotes, and their beat induces the flow of fluid …

Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa

DA Skerrett-Byrne, AL Anderson, EG Bromfield… - Cell Reports, 2022 - cell.com
Spermatozoa acquire fertilization potential during passage through a highly specialized
region of the extratesticular ductal system known as the epididymis. In the absence of de …

SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility

J Liu, L Hermo, D Ding, C Wei, JM Mann, X Yan… - Nature …, 2023 - nature.com
The cytoplasmic droplet is a conserved dilated area of cytoplasm situated at the neck of the
sperm flagellum. Viewed as residual cytoplasm inherited from late spermatids, the …

[HTML][HTML] Small RNA shuffling between murine sperm and their cytoplasmic droplets during epididymal maturation

H Wang, Z Wang, T Zhou, D Morris, S Chen, M Li… - Developmental cell, 2023 - cell.com
Reports that mouse sperm gain small RNAs from the epididymosomes secreted by
epididymal epithelial cells and that these" foreign" small RNAs act as an epigenetic …