Cancer therapeutics based on diverse energy sources

S Son, J Kim, J Kim, B Kim, J Lee, Y Kim, M Li… - Chemical Society …, 2022 - pubs.rsc.org
Light-based phototherapy has been developed for cancer treatment owing to its non-
invasiveness and spatiotemporal control. Despite the unique merits of phototherapy, one …

Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound

Z Xu, TL Hall, E Vlaisavljevich… - International Journal of …, 2021 - Taylor & Francis
Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology
guided by real-time imaging. Using focused ultrasound delivered from outside the body …

Applications of focused ultrasound for the treatment of glioblastoma: a new frontier

AM Hersh, M Bhimreddy, C Weber-Levine, K Jiang… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma (GBM) is a common primary brain tumor with a short median
overall survival despite aggressive treatment with resection, chemotherapy, and radiation …

Immunomodulation and targeted drug delivery with high intensity focused ultrasound (HIFU): Principles and mechanisms

H Ashar, A Ranjan - Pharmacology & Therapeutics, 2023 - Elsevier
High intensity focused ultrasound (HIFU) is a non-invasive and non-ionizing sonic energy-
based therapeutic technology for inducing thermal and non-thermal effects in tissues …

[HTML][HTML] Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy

S Qu, T Worlikar, AE Felsted, A Ganguly… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Developing the ability to use tumor-directed therapies to trigger potentially
therapeutic immune responses against cancer antigens remains a high priority for cancer …

Histotripsy: a method for mechanical tissue ablation with ultrasound

Z Xu, TD Khokhlova, CS Cho… - Annual Review of …, 2024 - annualreviews.org
Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy
tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to …

Immune modulation resulting from MR-guided high intensity focused ultrasound in a model of murine breast cancer

BZ Fite, J Wang, AJ Kare, A Ilovitsh, M Chavez… - Scientific reports, 2021 - nature.com
High intensity focused ultrasound (HIFU) rapidly and non-invasively destroys tumor tissue.
Here, we sought to assess the immunomodulatory effects of MR-guided HIFU and its …

The histotripsy spectrum: differences and similarities in techniques and instrumentation

RP Williams, JC Simon, VA Khokhlova… - International Journal …, 2023 - Taylor & Francis
Since its inception about two decades ago, histotripsy–a non-thermal mechanical tissue
ablation technique–has evolved into a spectrum of methods, each with distinct potentiating …

Immunological effects of histotripsy for cancer therapy

A Hendricks-Wenger, R Hutchison… - Frontiers in …, 2021 - frontiersin.org
Cancer is the second leading cause of death worldwide despite major advancements in
diagnosis and therapy over the past century. One of the most debilitating aspects of cancer …

High-intensity focused ultrasound (HIFU) triggers immune sensitization of refractory murine neuroblastoma to checkpoint inhibitor therapy

A Eranki, P Srinivasan, M Ries, AR Kim… - Clinical Cancer …, 2020 - AACR
Purpose: Immunotherapy promises unprecedented benefits to patients with cancer.
However, the majority of cancer types, including high-risk neuroblastoma, remain …