The insulin-like peptide (ILP) and insulin-like growth factor (IGF) signalling pathways play a
crucial role in the regulation of metabolism, growth and development, fecundity, stress …

Plasticity in animal behaviour relies on the ability to integrate external and internal cues from
the changing environment and hence modulate activity in synaptic circuits of the brain. This …

What are the spatial and temporal scales of brainwide neuronal activity? We used swept,
confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large …

The circadian clock and its output pathways play a pivotal role in optimizing daily processes.
To obtain insights into how diverse rhythmic physiology and behaviors are orchestrated, we …

Obesity imposes a global health threat and calls for safe and effective therapeutic options.
Here, we found that protein-rich diet significantly reduced body fat storage in fruit flies, which …

Infection with pathogenic microbes is a severe threat that hosts manage by activating the
innate immune response. In Drosophila melanogaster, the Toll and Imd signaling pathways …

Feeding decisions are fundamental to survival, and decision making is often disrupted in
disease. Here, we show that neural activity in a small population of neurons projecting to the …

The master circadian clock generates 24-hour rhythms to orchestrate daily behavior, even
running freely under constant conditions. Traditionally, the master clock is considered self …

Highlights•Drosophila glia share many properties with their mammalian
counterparts.•Different subpopulations of glia cells cooperate to support neuronal energy …

Neuropeptides are abundant signaling molecules that control neuronal activity and behavior
in all animals. Owing in part to its well-defined and compact nervous system, Caenorhabditis …