Myelodysplastic syndrome (MDS) is a clonal blood disorder characterized by ineffective
hematopoiesis, cytopenias, dysplasia and an increased risk of acute myeloid leukemia …

Shwachman-Diamond syndrome (SDS) is an autosomal-recessive inherited bone marrow
failure (BMF) disorder characterized by exocrine pancreatic dysfunction, BMF, and …

Neutropenia refers to a group of diseases characterized by a reduction in neutrophil levels
below the recommended age threshold. The present study aimed to review the diagnosis …

We report the outcomes of hematopoietic stem cell transplantation (HSCT) for 52 patients
with Shwachman-Diamond syndrome (SDS) who underwent transplantation between 2000 …

Inherited bone marrow failure syndromes (IBMFS) cause hematopoietic stem progenitor cell
(HSPC) failure due to germline mutations. Germline mutations influence the number and …

Both HSC cell-intrinsic and noncell-intrinsic changes contribute to the development of clonal
hematopoiesis in congenital neutropenia and likely accounts for the high rate of leukemic …

Inherited bone marrow failure syndromes and germline predisposition syndromes
(IBMFS/GPS) are associated with increased risk for hematologic malignancies, particularly …

Advanced myelodysplastic syndrome harbors a high risk of progression to acute myeloid
leukemia and poor prognosis. In children, there is no established treatment to prevent or …

Neutropenias (NPs), being acute and often transient, or chronic, range from life-threatening
conditions with very low absolute neutrophil blood counts (ANC) to disorders characterized …

Background Myelodysplastic syndromes (MDS) represent a group of clonal hematopoietic
stem cell disorders that commonly progress to acute myeloid leukemia (AML). The …