Trial watch: chemotherapy-induced immunogenic cell death in oncology
Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated cell
death that activates, rather than suppresses, innate and adaptive immune responses. Such …
death that activates, rather than suppresses, innate and adaptive immune responses. Such …
Pyroptosis and the cellular consequences of gasdermin pores
HC Huston, MJ Anderson, SL Fink - Seminars in immunology, 2023 - Elsevier
The family of gasdermin proteins plays a key role in the host response against external and
internal pathogenic signals by mediating the form of inflammatory regulated cell death …
internal pathogenic signals by mediating the form of inflammatory regulated cell death …
Targeting immunogenic cell stress and death for cancer therapy
Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …
stressors, occupies a central position in the development of novel anticancer treatments …
GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma
F Yang, T Xia, Z Zhao, J Lin, L Zhong, T Tang… - Cell Death & …, 2024 - nature.com
The metastasis or recurrence of rhabdomyosarcoma (RMS) is the primary cause of tumour-
related deaths. Patients with high-risk RMS have poor prognosis with a 5-year overall …
related deaths. Patients with high-risk RMS have poor prognosis with a 5-year overall …
Prognostic model revealing pyroptosis-related signatures in oral squamous cell carcinoma based on bioinformatics analysis
L Qi, Z Tang - Scientific Reports, 2024 - nature.com
One of the most common oral carcinomas is oral squamous cell carcinoma (OSCC), bringing
a heavy burden to global health. Although progresses have been made in the intervention of …
a heavy burden to global health. Although progresses have been made in the intervention of …
[HTML][HTML] Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity
G Jin, H Liu, Z Mei, Q Jin, S Ma, L Wang, Y Su, L Lv… - Bioactive Materials, 2025 - Elsevier
Tumor recurrence and metastasis after surgery are important factors affecting patient
survival. The immunosuppressed tumor microenvironment after surgery reduces the ability …
survival. The immunosuppressed tumor microenvironment after surgery reduces the ability …
[HTML][HTML] CircPDIA3/miR-449a/XBP1 feedback loop curbs pyroptosis by inhibiting palmitoylation of the GSDME-C domain to induce chemoresistance of colorectal …
J Lin, Z Lyu, H Feng, H Xie, J Peng, W Zhang… - Drug Resistance …, 2024 - Elsevier
Although oxaliplatin (OXA) is widely used in the frontline treatment of colorectal cancer
(CRC), CRC recurrence is commonly observed due to OXA resistance. OXA resistance is …
(CRC), CRC recurrence is commonly observed due to OXA resistance. OXA resistance is …
[HTML][HTML] Hepcidin Is a Valuable Therapeutic Target for Colorectal Cancer
R Frascatani, M Colella, G Monteleone - Cancers, 2024 - mdpi.com
Colorectal cancer (CRC) is one of the most frequent neoplasms and a major cause of cancer
death worldwide. Despite recent advances in treatment approaches, the prognosis of …
death worldwide. Despite recent advances in treatment approaches, the prognosis of …
Neobractatin induces pyroptosis of esophageal cancer cells by TOM20/BAX signaling pathway
Z Li, Z Bao, J Tan, G Chen, B Ye, J Zhao, L Zhang… - Phytomedicine, 2024 - Elsevier
Background Emerging evidence suggests that pyroptosis, a form of programmed cell death,
has been implicated in cancer progression. The involvement of specific proteins in …
has been implicated in cancer progression. The involvement of specific proteins in …
DNA methylation and its potential roles in common oral diseases
H Liu, L Ma, Z Cao - Life Sciences, 2024 - Elsevier
Oral diseases are among the most common diseases worldwide and are associated with
systemic illnesses, and the rising occurrence of oral diseases significantly impacts the …
systemic illnesses, and the rising occurrence of oral diseases significantly impacts the …