Trial watch: chemotherapy-induced immunogenic cell death in oncology

J Sprooten, RS Laureano, I Vanmeerbeek… - …, 2023 - Taylor & Francis
Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated cell
death that activates, rather than suppresses, innate and adaptive immune responses. Such …

Pyroptosis and the cellular consequences of gasdermin pores

HC Huston, MJ Anderson, SL Fink - Seminars in immunology, 2023 - Elsevier
The family of gasdermin proteins plays a key role in the host response against external and
internal pathogenic signals by mediating the form of inflammatory regulated cell death …

Targeting immunogenic cell stress and death for cancer therapy

L Galluzzi, E Guilbaud, D Schmidt, G Kroemer… - Nature Reviews Drug …, 2024 - nature.com
Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …

GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma

F Yang, T Xia, Z Zhao, J Lin, L Zhong, T Tang… - Cell Death & …, 2024 - nature.com
The metastasis or recurrence of rhabdomyosarcoma (RMS) is the primary cause of tumour-
related deaths. Patients with high-risk RMS have poor prognosis with a 5-year overall …

Prognostic model revealing pyroptosis-related signatures in oral squamous cell carcinoma based on bioinformatics analysis

L Qi, Z Tang - Scientific Reports, 2024 - nature.com
One of the most common oral carcinomas is oral squamous cell carcinoma (OSCC), bringing
a heavy burden to global health. Although progresses have been made in the intervention of …

[HTML][HTML] Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity

G Jin, H Liu, Z Mei, Q Jin, S Ma, L Wang, Y Su, L Lv… - Bioactive Materials, 2025 - Elsevier
Tumor recurrence and metastasis after surgery are important factors affecting patient
survival. The immunosuppressed tumor microenvironment after surgery reduces the ability …

[HTML][HTML] CircPDIA3/miR-449a/XBP1 feedback loop curbs pyroptosis by inhibiting palmitoylation of the GSDME-C domain to induce chemoresistance of colorectal …

J Lin, Z Lyu, H Feng, H Xie, J Peng, W Zhang… - Drug Resistance …, 2024 - Elsevier
Although oxaliplatin (OXA) is widely used in the frontline treatment of colorectal cancer
(CRC), CRC recurrence is commonly observed due to OXA resistance. OXA resistance is …

[HTML][HTML] Hepcidin Is a Valuable Therapeutic Target for Colorectal Cancer

R Frascatani, M Colella, G Monteleone - Cancers, 2024 - mdpi.com
Colorectal cancer (CRC) is one of the most frequent neoplasms and a major cause of cancer
death worldwide. Despite recent advances in treatment approaches, the prognosis of …

Neobractatin induces pyroptosis of esophageal cancer cells by TOM20/BAX signaling pathway

Z Li, Z Bao, J Tan, G Chen, B Ye, J Zhao, L Zhang… - Phytomedicine, 2024 - Elsevier
Background Emerging evidence suggests that pyroptosis, a form of programmed cell death,
has been implicated in cancer progression. The involvement of specific proteins in …

DNA methylation and its potential roles in common oral diseases

H Liu, L Ma, Z Cao - Life Sciences, 2024 - Elsevier
Oral diseases are among the most common diseases worldwide and are associated with
systemic illnesses, and the rising occurrence of oral diseases significantly impacts the …