Adenovirus infections in immunocompetent and immunocompromised patients

T Lion - Clinical microbiology reviews, 2014 - Am Soc Microbiol
Human adenoviruses (HAdVs) are an important cause of infections in both
immunocompetent and immunocompromised individuals, and they continue to provide …

Virus-specific T-cell banks for'off the shelf'adoptive therapy of refractory infections

RJ O'Reilly, S Prockop, AN Hasan, G Koehne… - Bone marrow …, 2016 - nature.com
Adoptive immunotherapy with transplant donor-derived virus-specific T cells has emerged
as a potentially curative approach for the treatment of drug-refractory EBV+ lymphomas as …

Off-the-shelf virus-specific T cells to treat BK virus, human herpesvirus 6, cytomegalovirus, Epstein-Barr virus, and adenovirus infections after allogeneic hematopoietic …

I Tzannou, A Papadopoulou, S Naik… - Journal of Clinical …, 2017 - ascopubs.org
Purpose Improvement of cure rates for patients treated with allogeneic hematopoietic stem-
cell transplantation (HSCT) will require efforts to decrease treatment-related mortality from …

Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors

A Bonifacius, B Lamottke… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND Adoptive transfer of EBV-specific T cells can restore specific immunity in
immunocompromised patients with EBV-associated complications. METHODS We provide …

Adenovirus infection and transplantation

OM Al-Heeti, HP Cathro, MG Ison - Transplantation, 2022 - journals.lww.com
Adenoviruses result in a wide array of clinical presentations, including primarily respiratory,
gastrointestinal, genitourinary, or systemic infections. Although adenovirus causes mild …

MVA vaccine encoding CMV antigens safely induces durable expansion of CMV-specific T cells in healthy adults

C La Rosa, J Longmate, J Martinez… - Blood, The Journal …, 2017 - ashpublications.org
Attenuated poxvirus modified vaccinia Ankara (MVA) is a useful viral-based vaccine for
clinical investigation, because of its excellent safety profile and property of inducing potent …

[HTML][HTML] Establishment and operation of a third-party virus-specific T cell bank within an allogeneic stem cell transplant program

B Withers, L Clancy, J Burgess, R Simms… - Biology of Blood and …, 2018 - Elsevier
Hematopoietic stem cell transplantation (HSCT) donor–generated virus-specific T cells
(VSTs) can provide effective treatment for viral infection post-HSCT but are not readily …

Adenovirus

MG Ison, RT Hayden - Diagnostic Microbiology of the …, 2016 - Wiley Online Library
Adenoviruses are non‐enveloped, double‐stranded deoxyribonucleic acid (DNA) viruses
associated with a wide range of clinical syndromes in humans (1, 2). To date, 67 …

[HTML][HTML] CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B* 35 control Epstein-Barr virus-associated lymphoproliferation

AC Dragon, K Zimmermann, T Nerreter… - … for Immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Immunosuppressive therapy or T-cell depletion in transplant patients can cause
uncontrolled growth of Epstein-Barr virus (EBV)-infected B cells resulting in post-transplant …

Addition of varicella zoster virus–specific T cells to cytomegalovirus, Epstein-Barr virus and adenovirus tri-specific T cells as adoptive immunotherapy in patients …

CKK Ma, E Blyth, L Clancy, R Simms, J Burgess… - Cytotherapy, 2015 - Elsevier
Background aims Virus-specific T-cell immunotherapy is emerging as a promising
management strategy for virus infections in patients after hematopoietic stem cell transplant …