Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …

Brain systems that promote the maintenance of homeostasis in face of stress have
significant adaptive value. A growing body of work across species demonstrates a critical …

Depression is a multifactorial disorder with clinically heterogeneous features involving
disturbances of mood and cognitive function. Noninvasive neuroimaging studies have …

In this Seminar we discuss developments from the past 5 years in the diagnosis,
neurobiology, and treatment of major depressive disorder. For diagnosis, psychiatric and …

The brain is the key organ of stress reactivity, coping, and recovery processes. Within the
brain, a distributed neural circuitry determines what is threatening and thus stressful to the …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

The brain is the key organ of stress processes. It determines what individuals will experience
as stressful, it orchestrates how individuals will cope with stressful experiences, and it …

Unravelling the pathophysiology of depression is a unique challenge. Not only are
depressive syndromes heterogeneous and their aetiologies diverse, but symptoms such as …

Women are twice as likely as men to develop major depressive disorder (MDD) and are
more prone to recurring episodes. Hence, we tested the hypothesis that the illness may …

Individual risk markers for depression and anxiety disorders have been identified but the
explicit pathways that link genes and environment to these markers remain unknown. Here …