Tumour-suppressor genes are indispensable for the maintenance of genomic integrity.
Recently, several of these genes, including those encoding p53, PTEN, RB1 and ARF, have …

Inactivation of the most important tumour suppressor gene TP53 occurs in most, if not all,
human cancers. Loss of functional wild-type p53 is achieved via two main mechanisms …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

The retinoic acid–inducible gene I (RIG-I) and melanoma differentiation–associated antigen
5 (MDA-5) helicases sense viral RNA in infected cells and initiate antiviral responses such …

Cancers are rare because their evolution is actively restrained by a range of tumour
suppressors. Of these p53 seems unusually crucial as either it or its attendant upstream or …

In the past 5 years, the field of oncolytic virus research has matured significantly and is
moving past the stage of being a laboratory novelty into a new era of preclinical and clinical …

Protection against cellular stress from various sources, such as nutritional, physical,
pathogenic, or oncogenic, results in the induction of both intrinsic and extrinsic cellular …

Tumor suppressor p53 is activated by several stimuli, including DNA damage and
oncogenic stress. Previous studies (Takaoka, A., S. Hayakawa, H. Yanai, D. Stoiber, H …

Infection by human coronaviruses is usually characterized by rampant viral replication and
severe immunopathology in host cells. Recently, the coronavirus papain-like proteases …

Resveratrol is a natural compound produced by certain plants on various stimuli. In recent
years, extensive research on resveratrol has been carried out, demonstrating its capacity to …