This review provides a personal account of the explorations of a research group in
oligosaccharide and glycoconjugate construction. The journey began twenty years ago with …

Although a bewildering array of cell surface carbohydrate structures have been described,
the physiological relevance of any of these complex molecules has often eluded biologists …

The carbohydrate antigen, sialyl Lex, is known to be a ligand for the cell adhesion molecule
called ELAM-1 (E-selectin, endothelial cell leukocyte adhesion molecule-1), which is …

The selectins (lectin-EGF-complement binding-cell adhesion molecules [LEC-CAMs]) are a
family of mammalian receptors implicated in the initial interactions between leukocytes and …

The leukocyte receptor CD62, which is expressed on activated platelets and endothelial
cells, is shown to mediate cell adhesion by binding a sialylated carbohydrate structure, sialyl …

The monoclonal antibody M-DC8 defines a major subset of human blood dendritic cells
(DCs). Here we identify the M-DC8 structure as 6-sulfo LacNAc, a novel carbohydrate …

Peptide ligands for the carbohydrate-binding protein concanavalin A (Con A) have been
identified by screening a large, diverse peptide library expressed on the surface of …

Recently the lectin-like domain on ELAM-1 (endothelial leukocyte adhesion molecule-1)
was shown to recognize a carbohydrate antigen, sialyl Lewis x. In this paper we …

Previously we have shown that high metastatic colonic carcinoma cells express relatively
more lamp molecules and sialyl Le (x) structures on the cell surface than their corresponding …

Aberrant glycosylation of glycoproteins and glycolipids of cancer cells, which correlates with
poor survival rates, is being exploited for the development of immunotherapies for cancer. In …