Bacterial quorum sensing and phenotypic heterogeneity: how the collective shapes the individual
B Striednig, H Hilbi - Trends in Microbiology, 2022 - cell.com
Bacteria communicate with each other through a plethora of small, diffusible organic
molecules called autoinducers. This cell-density-dependent regulatory principle is termed …
molecules called autoinducers. This cell-density-dependent regulatory principle is termed …
The Legionella pneumophila Dot/Icm type IV secretion system and its effectors
DC Lockwood, H Amin, TRD Costa… - …, 2022 - microbiologyresearch.org
To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …
Legionella‐ and host‐driven lipid flux at LCV‐ER membrane contact sites promotes vacuole remodeling
S Vormittag, D Hüsler, I Haneburger, T Kroniger… - EMBO …, 2023 - embopress.org
Legionella pneumophila replicates in macrophages and amoeba within a unique
compartment, the Legionella‐containing vacuole (LCV). Hallmarks of LCV formation are the …
compartment, the Legionella‐containing vacuole (LCV). Hallmarks of LCV formation are the …
Adaptations of intracellular bacteria to vacuolar or cytosolic niches
TJP Petit, A Lebreton - Trends in microbiology, 2022 - cell.com
Invasive bacteria colonise their host tissues by establishing niches inside eukaryotic cells,
where they grow either in the cytosol or inside a specialised vacuole. These two distinct …
where they grow either in the cytosol or inside a specialised vacuole. These two distinct …
A clash of quorum sensing vs quorum sensing inhibitors: an overview and risk of resistance
R Patel, M Soni, B Soyantar, S Shivangi… - Archives of …, 2023 - Springer
Indiscriminate use of antibiotics to treat microbial pathogens has caused emergence of
multiple drug resistant strains. Most infectious diseases are caused by microbes that are …
multiple drug resistant strains. Most infectious diseases are caused by microbes that are …
The large GTPase Sey1/atlastin mediates lipid droplet-and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila
D Hüsler, P Stauffer, B Keller, D Böck, T Steiner… - Elife, 2023 - elifesciences.org
The amoeba-resistant bacterium Legionella pneumophila causes Legionnaires' disease
and employs a type IV secretion system (T4SS) to replicate in the unique, ER-associated …
and employs a type IV secretion system (T4SS) to replicate in the unique, ER-associated …
RsaL-driven negative regulation promotes heterogeneity in Pseudomonas aeruginosa quorum sensing
M Mellini, M Letizia, L Caruso, A Guiducci… - Mbio, 2023 - Am Soc Microbiol
In its canonical interpretation, quorum sensing (QS) allows single cells in a bacterial
population to synchronize gene expression and hence perform specific tasks collectively …
population to synchronize gene expression and hence perform specific tasks collectively …
Nitric oxide signaling through three receptors regulates virulence, biofilm formation, and phenotypic heterogeneity of Legionella pneumophila
S Michaelis, T Chen, C Schmid, H Hilbi - Mbio, 2024 - Am Soc Microbiol
The causative agent of Legionnaires' disease, Legionella pneumophila, is an environmental
bacterium, that replicates in macrophages, parasitizes amoeba, and forms biofilms. L …
bacterium, that replicates in macrophages, parasitizes amoeba, and forms biofilms. L …
Pathogen vacuole membrane contact sites–close encounters of the fifth kind
S Vormittag, RJ Ende, I Derré, H Hilbi - Microlife, 2023 - academic.oup.com
Vesicular trafficking and membrane fusion are well-characterized, versatile, and
sophisticated means of 'long range'intracellular protein and lipid delivery. Membrane contact …
sophisticated means of 'long range'intracellular protein and lipid delivery. Membrane contact …
Intracellular persister: a stealth agent recalcitrant to antibiotics
N Personnic, P Doublet, S Jarraud - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
The bulk of bacteria transiently evading appropriate antibiotic regimes and recovered from
non-resolutive infections are commonly refer to as persisters. In this mini-review, we discuss …
non-resolutive infections are commonly refer to as persisters. In this mini-review, we discuss …