Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

Mitotic spindle positioning by cortical pulling forces defines the cell division axis and
location, which is critical for proper cell division and development. Although recent work has …

Maintaining genome integrity during cell division requires regulated interactions between
chromosomes and spindle microtubules. To ensure that daughter cells inherit the correct …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Mitotic spindle position defines the cell-cleavage site during cytokinesis. However, the
mechanisms that control spindle positioning to generate equal-sized daughter cells remain …

In eukaryotes, the spindle assembly checkpoint protects genome stability in mitosis by
preventing chromosome segregation until incorrect microtubule-kinetochore attachment …

Eukaryotic chromosome segregation relies upon specific connections from DNA to the
microtubule-based spindle that forms at cell division. The chromosomal locus that directs …

Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and
CEP63 colocalize at the centrosome. We found that they interact to promote centriole …

Chromosome alignment to the spindle equator is a hallmark of mitosis thought to promote
chromosome segregation fidelity in metazoans. Yet chromosome alignment is only indirectly …