Oncolytic adenovirus therapy is gaining importance as a novel treatment option for the
management of various cancers. Different concepts of modification within the adenovirus …

The ability of viruses to take over the synthetic machinery of the host cells they invade for
their own survival affords an ideal setting to look at the intricacies of ongoing regulation of …

The adenovirus early proteins E1A and E1B-55kDa are key regulators of viral DNA
replication, and it was thought that targeting of p53 by E1B-55kDa is essential for this …

We have examined the transcriptional regulation of the 70-kDa (70K) heat shock gene family
following infection of human and monkey cells with four different DNA viruses: adenovirus …

During human adenovirus 5 infection, a temporal cascade of gene expression leads
ultimately to the production of large amounts of the proteins needed to construct progeny …

The establishment of de novo patterns of DNA methylation in mammalian genomes is
characterized by the gradual spreading of methylation, which has been documented to …

Despite important advances in understanding the molecular basis of cancer, few treatments
have been devised which rationally target known causal oncogenic defects. Selectively …

Bearing in mind the limited success of available treatment modalities for the therapy of
multidrug-resistant tumor cells, alternative and complementary strategies need to be …

The adenovirus major late promoter (MLP) is active during both the early and late phases of
infection. During the early phase the activity of the MLP is similar to those of the other early …

Transcription from adenovirus E2-early promoter is controlled by a unique array of fourcis-
acting elements which include an atypical TBP site, two E2F sites present in an inverted …