Marketed therapies in the pharmaceutical landscape are rapidly evolving and getting more
diverse. Small molecule medicines have dominated in the past while antibodies have grown …

Mixed-mode high-performance liquid chromatography (MHPLC) is a type of
chromatographic technique with extraordinary separation properties, such as adjustable …

The composites of covalent organic frameworks (COFs) and silica gel have been considered
to be promising chromatographic separation materials due to the distinct advantages such …

We performed a systematic study of thirteen alkylamines used as ion-pairing reagents for ion-
pair reversed-phase liquid chromatography (IP RP LC) separations of oligonucleotides on a …

As interests increase in oligonucleotide therapeutics, there has been a greater need for
analytical techniques to properly analyze and quantitate these biomolecules. This article …

Oligonucleotides have emerged as powerful therapeutics for treating diverse diseases. To
fully unlock the therapeutic potential of oligonucleotides, there is still a great need to further …

In recent decades, there has been a trend toward using larger biological molecules as new
active pharmaceutical ingredients (APIs) instead of the classical small organic API …

Stationary phases with mixed-mode mechanisms have emerged as a hot research topic. In
the present research, monodisperse core–shell UiO-67@ SiO2 materials were prepared and …

The chemistry of guide RNA (gRNA) affects the performance of the clustered regularly
interspaced short palindromic repeats (CRISPR)-Cas9 genome editing technique. However …

Developing a versatile stationary phase to achieve the purpose of efficiently separating
various target analytes is of great significance. In this work, ureido/dodecyl dual …