ATP-binding cassette (ABC) transporters such as ABCB1, ABCG2, and ABCC1 are the
major players in drug efflux-mediated multidrug resistance (MDR), which severely affects the …

Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a
leading cause of cancer deaths worldwide. Chemotherapy as monotherapy can lead to …

Introduction P53 represents a key player in apoptosis-induction in cancers including
colorectal cancer (CRC) that ranks third worldwide in cancer prevalence as well as mortality …

Cancer is one of the most serious public health issues worldwide, demanding ongoing
efforts to find novel therapeutic agents and approaches. Amid growing interest in the …

Cancer cell plasticity plays a crucial role in tumor initiation, progression, and metastasis and
is implicated in the multiple cancer defense mechanisms associated with therapy resistance …

One of the primary diseases that cause death worldwide is cancer. Cancer cells can be
intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment …

Diseases are evolving as living standards continue to improve. Cancer is the main cause of
death and a major public health problem that seriously threatens human life. Colorectal …

Abstract B7-H3 (B7 homology 3 protein) is an important transmembrane immunoregulatory
protein expressed in immune cells, antigen-presenting cells, and tumor cells. Studies reveal …

Background Colorectal cancer (CRC), which is mainly caused by epigenetic and lifestyle
factors, is very often associated with functional plasticity during its development. In addition …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Despite significant
advances in medical treatment, chemotherapy as monotherapy can lead to substantial side …