Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin—A mini-review

A Roohbakhsh, H Parhiz, F Soltani, R Rezaee… - Life sciences, 2014 - Elsevier
Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species
that have various biological properties. Over the past decade, a large number of papers …

Endocannabinoids, cannabinoids and the regulation of anxiety

GN Petrie, AS Nastase, RJ Aukema, MN Hill - Neuropharmacology, 2021 - Elsevier
Cannabis has been used for hundreds of years, with its ability to dampen feelings of anxiety
often reported as a primary reason for use. Only recently has the specific role cannabinoids …

TRPV1 in the central nervous system: synaptic plasticity, function, and pharmacological implications

JG Edwards - Capsaicin as a therapeutic molecule, 2014 - Springer
The function of TRPV1 in the peripheral nervous system is increasingly being investigated
for its anti-inflammatory and antinociceptive properties in an effort to find a novel target to …

Noopept attenuates diabetes-mediated neuropathic pain and oxidative hippocampal neurotoxicity via inhibition of TRPV1 channel in rats

H Düzova, M Nazıroğlu, B Çiğ, P Gürbüz… - Molecular …, 2021 - Springer
Neuropathic pain and oxidative neurotoxicity are two adverse main actions of diabetes
mellitus (DM). The expression levels of calcium ion (Ca 2+) permeable TRPV1 channels are …

[HTML][HTML] Crocin improved learning and memory impairments in streptozotocin-induced diabetic rats

E Tamaddonfard, AA Farshid… - Iranian journal of …, 2013 - ncbi.nlm.nih.gov
Objective (s): Crocin influences many biological functions including memory and learning.
The present study was aimed to investigate the effects of crocin on learning and memory …

[HTML][HTML] Cannabinoid modulation of the stressed hippocampus

FF Scarante, C Vila-Verde, VL Detoni… - Frontiers in molecular …, 2017 - frontiersin.org
Exposure to stressful situations is one of the risk factors for the precipitation of several
psychiatric disorders, including Major Depressive Disorder, Posttraumatic Stress Disorder …

[HTML][HTML] Ventral hippocampal diacylglycerol lipase-alpha deletion decreases avoidance behaviors and alters excitation-inhibition balance

V Kondev, R Bluett, M Najeed, LE Rosas-Vidal… - Neurobiology of …, 2023 - Elsevier
Abstract The endogenous cannabinoid, 2-arachidonoylglycerol (2-AG), plays a key role in
the regulation of anxiety-and stress-related behavioral phenotypes and may represent a …

The endocannabinoid system and anxiety

SF Lisboa, FV Gomes, ALB Terzian, DC Aguiar… - Vitamins and …, 2017 - Elsevier
The medical properties of Cannabis sativa is known for centuries. Since the discovery and
characterization of the endogenous cannabinoid system, several studies have evaluated …

Central administration of GPR 55 receptor agonist and antagonist modulates anxiety‐related behaviors in rats

A Rahimi, A Hajizadeh Moghaddam… - Fundamental & …, 2015 - Wiley Online Library
Abstract G‐protein‐coupled receptor 55 (GPR 55) has been proposed as an atypical
cannabinoid receptor, which is activated by lysophosphatidylinositols and some synthetic or …

[HTML][HTML] Increased TRPV1 channels and FosB protein expression are associated with chronic epileptic seizures and Anxiogenic-like behaviors in a preclinical model …

W Lazarini-Lopes, GK Silva-Cardoso… - Biomedicines, 2022 - mdpi.com
Epilepsies are neurological disorders characterized by chronic seizures and their related
neuropsychiatric comorbidities, such as anxiety. The Transient Receptor Potential Vanilloid …