Biofilm formation and biofilm-induced biodeterioration of surfaces have deeply affected the
life of our community. Cyclic dimeric guanosine monophosphate (c-di-GMP) is a small …

Microbial biofilms are the cause of persistent infections associated with various medical
implants and distinct body sites such as the urinary tract, lungs, and wounds. Compared with …

Cyclic di-adenosine monophosphate (c-di-AMP) is a recently discovered bacterial second
messenger implicated in the control of cell wall metabolism, osmotic stress responses and …

We describe novel STING-activating cyclic dinucleotides whose constituent nucleosides are
adenosine and inosine and that vary by ribose substitution, internucleotide linkage position …

The rise of bacterial resistance to traditional antibiotics has motivated recent efforts to
identify new drug candidates that target virulence factors or their regulatory pathways. One …

Bacteria utilize nucleotide-based second messengers to regulate a myriad of physiological
processes. Cyclic dinucleotides have emerged as central regulators of bacterial physiology …

Over 30 years ago, GGDEF domain-containing enzymes were shown to be diguanylate
cyclases that produce cyclic di-GMP (cdiG), a second messenger that modulates the key …

2016-05-02 Assigned to MEMORIAL SLOAN KETTERING CANCER CENTER reassignment
MEMORIAL SLOAN KETTERING CANCER CENTER ASSIGNMENT OF ASSIGNORS …

The majority of bacteria in the natural environment organize themselves into communal
biofilms. Biofilm formation benefits bacteria conferring resistance to harmful molecules (eg …

Cyclic di-GMP is a second messenger found in almost all eubacteria that acts to regulate a
wide range of functions including developmental transitions, adhesion and biofilm formation …