Since its discovery over four decades ago, somatostatin (SOM) receives growing scientific
and clinical interest. Being localized in the nervous system in a subset of interneurons …

Alzheimer's and Parkinson's diseases are the most prevalent neurodegenerative disorders
in aging. Hyposmia has been described as an early symptom that can precede cognitive …

Deficits in odor identification and detection are early symptoms of Alzheimer's disease (AD).
Two transgenic mouse models of AD, the 5XFAD and the 3× Tg-AD mice and their wildtype …

In Alzheimer's disease, the tauopathy is known as a major mechanism responsible for the
development of cognitive deficits. Early biomarkers of such affectations for …

The neuropeptide somatostatin (SOM) is widely expressed in rodent brain and somatostatin-
IRES-Cre (SOM-cre) mouse strains are increasingly used to unravel the physiology of SOM …

Somatostatin (SOM) and somatostatin receptors (SSTR1–4) are present in all olfactory
structures, including the olfactory bulb (OB), where SOM modulates physiological gamma …

Abstract A neuropeptidase, neprilysin (NEP), is a major amyloid (Aβ)-degrading enzyme
involved in the pathogenesis of Alzheimer's disease (AD). The olfactory system is affected …

Early life adversity (ELA) causes aberrant functioning of neural circuits affecting the health of
an individual. While ELA-induced behavioural disorders resulting from sensory and …

Intelligent systems in nature like the mammalian nervous system benefit from adaptable
inputs that can tailor response profiles to their environment that varies in time and space …

Sensory processing is susceptible to decline with age. The sense of taste is, however,
generally thought to be resistant to aging. We investigated how chorda-tympani nerve …