Apicomplexans, including species of Eimeria, pose a real threat to the health and wellbeing
of animals and humans. Eimeria parasites do not infect humans but cause an important …

Host cell exit is a critical step in the life-cycle of intracellular pathogens, intimately linked to
barrier penetration, tissue dissemination, inflammation, and pathogen transmission. Like cell …

Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for
microneme secretion, motility, invasion, and egress in apicomplexan parasites, However …

Protein kinases regulate fundamental aspects of eukaryotic cell biology, making them
attractive chemotherapeutic targets in parasites like Plasmodium spp. and Toxoplasma …

Toxoplasma gondii establishes a lifelong chronic infection in humans and animals. Host cell
entry and egress are key steps in the lytic cycle of this obligate intracellular parasite …

Apicomplexan parasites cause persistent mortality and morbidity worldwide through
diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca 2+ signaling pathways …

Toxoplasma gondii encodes three protein kinase A catalytic (PKA c1‐3) and one regulatory
(PKA r) subunits to integrate cAMP‐dependent signals. Here, we show that inactive PKA c1 …

Toxoplasma gondii contains an expanded number of calmodulin (CaM)-like proteins whose
functions are poorly understood. Using a combination of CRISPR/Cas9-mediated gene …

Apicomplexan parasites are typified by an apical complex that contains a unique
microtubule-organizing center (MTOC) that organizes the cytoskeleton. In apicomplexan …

Apicomplexan parasites rely on cyclic nucleotide-dependent kinases for host cell infection,
yet the mechanisms that control their activation remain unknown. Here we show that an …