Natural products for human health: an historical overview of the drug discovery approaches
S Bernardini, A Tiezzi, V Laghezza Masci… - Natural product …, 2018 - Taylor & Francis
Natural products (NPs) are secondary metabolites produced and used by organisms for
defending or adapting purposes. These molecules were naturally selected during thousands …
defending or adapting purposes. These molecules were naturally selected during thousands …
The pharmaceutical industry and natural products: historical status and new trends
Owing to the high diversity of terrestrial and marine organisms, natural products (secondary
metabolites) are some of the most successful source of drug leads for the treatment of many …
metabolites) are some of the most successful source of drug leads for the treatment of many …
Modern natural products drug discovery and its relevance to biodiversity conservation
DGI Kingston - Journal of natural products, 2011 - ACS Publications
Natural products continue to provide a diverse and unique source of bioactive lead
compounds for drug discovery, but maintaining their continued eminence as source …
compounds for drug discovery, but maintaining their continued eminence as source …
Dereplication: racing to speed up the natural products discovery process
SP Gaudêncio, F Pereira - Natural product reports, 2015 - pubs.rsc.org
Covering: 1993–2014 (July) To alleviate the dereplication holdup, which is a major
bottleneck in natural products discovery, scientists have been conducting their research …
bottleneck in natural products discovery, scientists have been conducting their research …
Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approach
IM Kapetanovic - Chemico-biological interactions, 2008 - Elsevier
It is generally recognized that drug discovery and development are very time and resources
consuming processes. There is an ever growing effort to apply computational power to the …
consuming processes. There is an ever growing effort to apply computational power to the …
Recent advances in natural products from plants for treatment of liver diseases
A Zhang, H Sun, X Wang - European journal of medicinal chemistry, 2013 - Elsevier
Liver disease is any condition that may cause liver inflammation or tissue damage and
affects liver function. Natural products that are found in vegetables, fruits, plant extracts …
affects liver function. Natural products that are found in vegetables, fruits, plant extracts …
Plant natural products: back to the future or into extinction?
JD McChesney, SK Venkataraman, JT Henri - Phytochemistry, 2007 - Elsevier
Natural product substances have historically served as the most significant source of new
leads for pharmaceutical development. However, with the advent of robotics, bioinformatics …
leads for pharmaceutical development. However, with the advent of robotics, bioinformatics …
6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection
Inflammatory processes in the central nervous system play an important role in a number of
neurodegenerative diseases mediated by microglial activation, which results in neuronal …
neurodegenerative diseases mediated by microglial activation, which results in neuronal …
Virtual screening for the discovery of bioactive natural products
JM Rollinger, H Stuppner, T Langer - Natural compounds as drugs …, 2008 - Springer
In this survey the impact of the virtual screening concept is discussed in the field of drug
discovery from nature. Confronted by a steadily increasing number of secondary metabolites …
discovery from nature. Confronted by a steadily increasing number of secondary metabolites …
Multi-targeted natural products evaluation based on biological activity prediction with PASS
A Lagunin, D Filimonov… - Current Pharmaceutical …, 2010 - ingentaconnect.com
Natural products found a wide use in folk medicine. Presently, when routine development of
new drugs faced a considerable challenge, they become an inspiration and valuable source …
new drugs faced a considerable challenge, they become an inspiration and valuable source …