Natural products for human health: an historical overview of the drug discovery approaches

S Bernardini, A Tiezzi, V Laghezza Masci… - Natural product …, 2018 - Taylor & Francis
Natural products (NPs) are secondary metabolites produced and used by organisms for
defending or adapting purposes. These molecules were naturally selected during thousands …

The pharmaceutical industry and natural products: historical status and new trends

B David, JL Wolfender, DA Dias - Phytochemistry Reviews, 2015 - Springer
Owing to the high diversity of terrestrial and marine organisms, natural products (secondary
metabolites) are some of the most successful source of drug leads for the treatment of many …

Modern natural products drug discovery and its relevance to biodiversity conservation

DGI Kingston - Journal of natural products, 2011 - ACS Publications
Natural products continue to provide a diverse and unique source of bioactive lead
compounds for drug discovery, but maintaining their continued eminence as source …

Dereplication: racing to speed up the natural products discovery process

SP Gaudêncio, F Pereira - Natural product reports, 2015 - pubs.rsc.org
Covering: 1993–2014 (July) To alleviate the dereplication holdup, which is a major
bottleneck in natural products discovery, scientists have been conducting their research …

Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approach

IM Kapetanovic - Chemico-biological interactions, 2008 - Elsevier
It is generally recognized that drug discovery and development are very time and resources
consuming processes. There is an ever growing effort to apply computational power to the …

Recent advances in natural products from plants for treatment of liver diseases

A Zhang, H Sun, X Wang - European journal of medicinal chemistry, 2013 - Elsevier
Liver disease is any condition that may cause liver inflammation or tissue damage and
affects liver function. Natural products that are found in vegetables, fruits, plant extracts …

Plant natural products: back to the future or into extinction?

JD McChesney, SK Venkataraman, JT Henri - Phytochemistry, 2007 - Elsevier
Natural product substances have historically served as the most significant source of new
leads for pharmaceutical development. However, with the advent of robotics, bioinformatics …

6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection

SK Ha, E Moon, MS Ju, DH Kim, JH Ryu, MS Oh… - …, 2012 - Elsevier
Inflammatory processes in the central nervous system play an important role in a number of
neurodegenerative diseases mediated by microglial activation, which results in neuronal …

Virtual screening for the discovery of bioactive natural products

JM Rollinger, H Stuppner, T Langer - Natural compounds as drugs …, 2008 - Springer
In this survey the impact of the virtual screening concept is discussed in the field of drug
discovery from nature. Confronted by a steadily increasing number of secondary metabolites …

Multi-targeted natural products evaluation based on biological activity prediction with PASS

A Lagunin, D Filimonov… - Current Pharmaceutical …, 2010 - ingentaconnect.com
Natural products found a wide use in folk medicine. Presently, when routine development of
new drugs faced a considerable challenge, they become an inspiration and valuable source …