The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …

Integrated in vitro models of human organogenesis are needed to elucidate the multi-
systemic events underlying development and disease. Here we report the generation of …

The mammalian spinal cord functions as a community of cell types for sensory processing,
autonomic control, and movement. While animal models have advanced our understanding …

The development of the vertebrate spinal cord involves the formation of the neural tube and
the generation of multiple distinct cell types. The process starts during gastrulation …

Understanding spinal cord assembly is essential to elucidate how motor behavior is
controlled and how disorders arise. The human spinal cord is exquisitely organized, and this …

Abstract Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97%
of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been …

The nervous system is one of the most sophisticated animal tissues, consisting of thousands
of interconnected cell types. How the nervous system develops its diversity from a few neural …

The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate
nervous system are incompletely understood. Here, we provide evidence of a global …

Ageing is a critical factor in spinal-cord-associated disorders, yet the ageing-specific
mechanisms underlying this relationship remain poorly understood. Here, to address this …

Spinal motor neurons (MNs) integrate sensory stimuli and brain commands to generate
movements. In vertebrates, the molecular identities of the cardinal MN types such as those …