Sequential and direct multicomponent reaction (MCR)-based dearomatization strategies
Dearomatization strategies in a multicomponent fashion often result in complex heterocyclic
frameworks, which have attracted the attention of chemists due to their natural product-like …
frameworks, which have attracted the attention of chemists due to their natural product-like …
Chemodivergent reactions
IP Beletskaya, C Nájera, M Yus - Chemical Society Reviews, 2020 - pubs.rsc.org
An important strategy for the efficient generation of diversity in molecular structures is the
utilization of common starting materials in chemodivergent transformations. The most …
utilization of common starting materials in chemodivergent transformations. The most …
Cooperative N-heterocyclic carbene/palladium-catalyzed enantioselective umpolung annulations
C Guo, M Fleige, D Janssen-Müller… - Journal of the …, 2016 - ACS Publications
A combination of NHC organocatalysis and transition-metal catalysis gives rise to
fundamentally new cooperative reactivity and enables the regio-and enantioselective …
fundamentally new cooperative reactivity and enables the regio-and enantioselective …
Switchable divergent asymmetric synthesis via organocatalysis
G Zhan, W Du, YC Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
The development of switchable chemo-, regio-, or diastereodivergent reactions, in which two
or more structurally and stereogenically different types of chiral products could be produced …
or more structurally and stereogenically different types of chiral products could be produced …
Highly enantioselective [5+ 2] annulations through cooperative N-heterocyclic carbene (NHC) organocatalysis and palladium catalysis
The highly enantioselective [5+ 2] annulation of enals with vinylethylene carbonates through
a cooperative N-heterocyclic carbene (NHC)/Pd catalytic system is reported. The use of a …
a cooperative N-heterocyclic carbene (NHC)/Pd catalytic system is reported. The use of a …
Catalyst‐Controlled Switch in Chemo‐and Diastereoselectivities: Annulations of Morita–Baylis–Hillman Carbonates from Isatins
G Zhan, ML Shi, Q He, WJ Lin… - Angewandte Chemie …, 2016 - Wiley Online Library
Regulating both the chemo‐and diastereoselectivity, divergently, of a reaction is highly
attractive but extremely challenging. Presented herein is a catalyst‐controlled switch in the …
attractive but extremely challenging. Presented herein is a catalyst‐controlled switch in the …
Mechanistic Studies on a Cooperative NHC Organocatalysis/Palladium Catalysis System: Uncovering Significant Lessons for Mixed Chiral Pd(NHC)(PR3) Catalyst …
C Guo, D Janssen-Müller, M Fleige… - Journal of the …, 2017 - ACS Publications
A comprehensive investigation of the mechanism of the highly enantioselective Pd (PPh3)
4/NHC-catalyzed annulation of vinyl benzoxazinanones and enals has been conducted. A …
4/NHC-catalyzed annulation of vinyl benzoxazinanones and enals has been conducted. A …
Cooperative N-heterocyclic carbene and iridium catalysis enables stereoselective and regiodivergent [3+ 2] and [3+ 3] annulation reactions
J Zhang, YS Gao, BM Gu, WL Yang, BX Tian… - ACS …, 2021 - ACS Publications
A cooperative N-heterocyclic carbene (NHC)/iridium catalysis has been developed to
achieve highly stereoselective and regiodivergent [3+ 2] and [3+ 3] annulation reactions of 2 …
achieve highly stereoselective and regiodivergent [3+ 2] and [3+ 3] annulation reactions of 2 …
N‐Heterocyclic Carbene (NHC)‐Catalyzed Transformations Involving Azolium Enolates
The recent advances in the N‐heterocyclic carbene (NHC)‐organocatalyzed generation of
azolium enolate intermediates and their subsequent interception with electrophiles are …
azolium enolate intermediates and their subsequent interception with electrophiles are …
Ir and NHC dual chiral synergetic catalysis: mechanism and stereoselectivity in γ-butyrolactone formation
Cooperative dual catalysis is a powerful strategy for achieving unique reactivity by
combining catalysts with orthogonal modes of action. This approach allows for independent …
combining catalysts with orthogonal modes of action. This approach allows for independent …