The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of
proliferation, differentiation and survival. The induction of these pathways depends on …

Extracellular signal-regulated kinase 5 (ERK5), also termed big mitogen-activated protein
kinase-1 (BMK1), is the most recently identified member of the mitogen-activated protein …

The MEK5/ERK5 mitogen-activated protein kinases (MAPK) cascade is a unique signaling
module activated by both mitogens and stress stimuli, including cytokines, fluid shear stress …

Acute kidney injury (AKI) promotes an abrupt loss of kidney function that results in
substantial morbidity and mortality. Considerable effort has gone toward identification of …

Abstract The Pattern Of Invasion (POI) of tumor cells into adjacent normal tissues clinically
predicts postoperative tumor metastasis/recurrence of early oral squamous cell carcinoma …

Diffuse gliomas are devastating brain tumors. Here, we perform a proteogenomic profiling of
213 retrospectively collected glioma tumors. Proteogenomic analysis reveals the …

Small amounts of carbon monoxide (CO) are continuously produced in mammals. The
intracellular levels of CO can increase under stressful conditions following the induction of …

Small-cell lung cancer (SCLC) is an aggressive form of lung cancer with dismal survival
rates. While kinases often play key roles driving tumorigenesis, there are strikingly few …

Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with
transcriptional activation capability in addition to an N-terminal canonical kinase domain …

Highlights•The present review highlights the emerging clinical relevance of MEK5/ERK5
signalling as a therapeutic target and prognostic factor in several top-leading diagnosed …