Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …

Multifactorial diseases exhibit a complex pathophysiology with several factors contributing to
their pathogenesis and development. Examples of such disorders are neurodegenerative …

4-Mercaptoimidazole (4MC) is related to natural ovothiols known to be potent radical
scavengers. In spite of early reports of its good antioxidant activity, 4MC has attracted little …

Inhibition of aldose reductase (AR), the first enzyme of the polyol pathway, is a promising
approach in treatment of diabetic complications. We proceeded with optimization of the …

Aldose reductase (AR, ALR2), the first enzyme of the polyol pathway, is implicated in the
pathophysiology of diabetic complications. Aldose reductase inhibitors (ARIs) thus present a …

Hyperglycemia is considered a key risk factor for development of diabetic complications
including neuropathy. There is strong scientific evidence showing a primary role of aldose …

Peripheral neuropathy is the most prevalent chronic complication of diabetes mellitus. Good
glycemic control can delay the appearance of neuropathic symptoms in diabetic patients but …

Aldose reductase (AR) catalyzes the conversion of glucose to sorbitol in a NADPH-
dependent reaction, thereby increasing the production of reactive oxygen species (ROS) …

Neuroprotective action of the novel aldose reductase (AR) inhibitor cemtirestat (CMT), 2-(3-
thioxo-2H-[1, 2, 4] triazino [5, 6-b] indol-5 (3H)-yl) acetic acid, was recently proved in …

Indole derivatives such as isatin (a natural compound), cemtirestat, stobadine, and its
derivatives (synthetic compounds) are known to have numerous positive effects on human …