Chronic wounds often occur in patients with diabetes mellitus due to the impairment of
wound healing. This has negative consequences for both the patient and the medical …

Akt kinase, a member of AGC kinases, is important in many cellular functions including
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …

Background Cardiovascular risk factors contribute to atherogenesis by inducing endothelial-
cell injury and dysfunction. We hypothesized that endothelial progenitor cells derived from …

The endothelium exerts multiple actions involving regulation of vascular permeability and
tone, coagulation and fibrinolysis, inflammatory and immunological reactions and cell …

With the discovery of endothelial progenitor cells (EPCs) in the late 1990s, a paradigm shift
in the concept of neoangiogenesis occurred. The identification of circulating EPCs in …

The trafficking of circulating stem and progenitor cells to areas of tissue damage is poorly
understood. The chemokine stromal cell–derived factor-1 (SDF-1 or CXCL12) mediates …

▪ Abstract Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are
beneficial in the primary and secondary prevention of coronary heart disease. However, the …

Background Endothelial progenitor cells derived from bone marrow are believed to support
the integrity of the vascular endothelium. The number and function of endothelial progenitor …

Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be
beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for …

Human bone marrow‐derived mesenchymal stem cells (MSCs) have the potential to
differentiate into mesenchymal tissues like osteocytes, chondrocytes, and adipocytes in vivo …